73914
鞘氨醇-1-磷酸
≥98.0% (TLC)
别名:
D-赤式-鞘氨醇-1-磷酸, （2S，3[R，4E）-2-氨基-4-十八碳烯-1,3-二醇1-磷酸酯
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关于此项目
经验公式（希尔记法）:
C18H38NO5P
化学文摘社编号:
分子量:
379.47
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
产品名称
鞘氨醇-1-磷酸, ≥98.0% (TLC)
InChI
1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
SMILES string
CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O
InChI key
DUYSYHSSBDVJSM-KRWOKUGFSA-N
assay
≥98.0% (TLC)
form
powder
composition
carbon content, 56.97%
hydrogen content, 10.09%
nitrogen content, 3.69%
lipid type
sphingolipids
storage temp.
−20°C
Quality Level
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相关类别
Application
西尼莫德治疗骨质疏松症的再利用：一项研究重点介绍了西尼莫德（最初为多发性硬化症开发的S1P受体调节剂）通过影响鞘氨醇1-磷酸途径治疗骨质疏松症的潜力（Hu et al., 2024）。
鞘氨醇-1-磷酸在眼部健康中的作用：研究表明，鞘氨醇-1-磷酸受体1/5的选择性激动剂可以减轻眼部血管病变，表明其在眼病管理中具有治疗潜力，它还负责调节细胞存活、分化和增殖等多种细胞内过程（Nakamura et al., 2024）。
针对糖尿病肾病：研究探讨了车前子通过鞘氨醇激酶1/鞘氨醇-1-磷酸途径改善糖尿病肾病的机制，强调了该途径在代谢健康中的作用（Lan et al., 2024）。
神经退行性疾病治疗的进展：一篇综述聚焦于靶向鞘氨醇-1-磷酸受体的小分子调节剂的研究进展，为治疗神经退行性疾病指明了新方向（Sankar Kar et al., 2024）。
鞘氨醇-1-磷酸在眼部健康中的作用：研究表明，鞘氨醇-1-磷酸受体1/5的选择性激动剂可以减轻眼部血管病变，表明其在眼病管理中具有治疗潜力，它还负责调节细胞存活、分化和增殖等多种细胞内过程（Nakamura et al., 2024）。
针对糖尿病肾病：研究探讨了车前子通过鞘氨醇激酶1/鞘氨醇-1-磷酸途径改善糖尿病肾病的机制，强调了该途径在代谢健康中的作用（Lan et al., 2024）。
神经退行性疾病治疗的进展：一篇综述聚焦于靶向鞘氨醇-1-磷酸受体的小分子调节剂的研究进展，为治疗神经退行性疾病指明了新方向（Sankar Kar et al., 2024）。
Biochem/physiol Actions
可与S1P1 和S1P3 受体结合的脂质第二信使。调动细胞内Ca2+ 储备并降低细胞cAMP。激活磷脂酶D。S1P可刺激内皮细胞的迁移，但抑制其他细胞类型细胞的迁移。 诱导血管生成。
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Tal I Arnon et al.
Current topics in microbiology and immunology, 378, 107-128 (2014-04-15)
The spleen, the largest secondary lymphoid organ, has long been known to play important roles in immunity against blood-borne invaders. Yet how cells migrate within the spleen to ensure fast and effective responses is only now coming to light. Chemokines
Craig T Wallington-Beddoe et al.
British journal of haematology, 161(5), 623-638 (2013-03-26)
The sphingosine kinases (SphKs) have relatively recently been implicated in contributing to malignant cellular processes with particular interest in the oncogenic properties of SPHK1. Whilst SPHK1 has received considerable attention as a putative oncoprotein, SPHK2 has been much more difficult
Alexander Koch et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 31(6), 745-760 (2013-06-06)
Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about the physiological and
Emmanuel E Egom et al.
Current opinion in lipidology, 24(4), 351-356 (2013-05-09)
The absolute level of HDL cholesterol (HDL-C) may not be the only criterion contributing to their antiatherothrombotic effects. This review focuses on evidence in support of the concept that HDL-bound sphingosine-1-phosphate (S1P) plays a role in different HDL atheroprotective properties
Gregory T Kunkel et al.
Nature reviews. Drug discovery, 12(9), 688-702 (2013-08-21)
The bioactive lipid sphingosine-1-phosphate (S1P) is involved in multiple cellular signalling systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has been implicated in disorders such as cancer and inflammatory diseases. This Review
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