biological source
Streptomyces noursei
Quality Segment
assay
≥85% (HPLC)
form
solid
color
white to light brown
solubility
H2O: soluble 200 mg/mL
suitability
suitable for (selection agent for molecular genetic research work)
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, fungi, mycobacteria, mycoplasma, parasites, viruses, yeast
mode of action
protein synthesis | interferes
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(O)O.N4[C@H]5[C@H](N=C4N[C@@H]6O[C@@H]([C@@H]([C@H]([C@H]6NC(=O)C[C@@H](N)CCCNC(=O)C[C@@H](N)CCCNC(=O)C[C@@H](N)CCCN)O)OC(=O)N)CO)C(=O)NC[C@H]5O.N1[C@H]2[C@H](N=C1N[C@@H]3O[C@@H]([C@@H]([C@H]([C@H]3NC(=O)C[C@@H](N)CCCN)O)OC(=O)N)CO)C(=O)NC[C@H]
InChI key
HEPYPTBGGNPPAP-SPCBHCMPSA-N
General description
Chemical structure: peptidyl nucleoside
Application
Noursethricin is used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa and plants.
Biochem/physiol Actions
Antifungal effective against Candida albicans. Candida species transformed with the gene encoding nourseothricin acetyltransferase (CaNAT1) were resistant to nourseothricin.
Nourseothricin inhibits biosynthesis and induces miscoding. Resistance to nourseothricin is mediated by the sat1 encoded N-acetyltransferase. Nourseothricin is inactivated by acetylation of the β-amino group of the β-lysin.
Packaging
10mg, 100mg
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.
警示词
Warning
危险代码
Hazard Classifications
Acute Tox. 4 Oral
存储类别
13 - Non Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable
PPE（个人防护设备）
dust mask type N95 (US), Eyeshields, Gloves