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Merck
CN

77739

Sigma-Aldrich

Pefachrome® Fxa

≥95.0% (HPLC)

别名:

N-Methoxycarbonyl-D-cyclohexylalanyl-glycyl-L-arginine-4-nitroanilide acetate, N-Methoxycarbonyl-D-Cha-Gly-Arg-4-nitroanilide acetate

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关于此项目

经验公式（希尔记法）:
C25H38N8O7 · C2H4O2
化学文摘社编号:
80895-10-9
分子量:
622.67
MDL编号:
MFCD03791099
UNSPSC代码:
12352200
PubChem化学物质编号:
57652710

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方案

≥95.0% (HPLC)

表单

powder

溶解性

water: 1 mg/mL, clear, colorless

适用性

degradable with trypsin for enzyme test (substrate for Factor Xa)

储存温度

2-8°C

SMILES字符串

CC(O)=O.COC(=O)N[C@H](CC1CCCCC1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)Nc2ccc(cc2)[N+]([O-])=O

InChI

1S/C25H38N8O7.C2H4O2/c1-40-25(37)32-20(14-16-6-3-2-4-7-16)22(35)29-15-21(34)31-19(8-5-13-28-24(26)27)23(36)30-17-9-11-18(12-10-17)33(38)39;1-2(3)4/h9-12,16,19-20H,2-8,13-15H2,1H3,(H,29,35)(H,30,36)(H,31,34)(H,32,37)(H4,26,27,28);1H3,(H,3,4)/t19-,20+;/m0./s1

InChI key

QXWRKXQCMBOLJR-CMXBXVFLSA-N

应用

Pefachrome® substrates are used for chromogenic assays of various serine proteinases. Pefachrome® Fxa is used for the detection of serine proteases such as blood coagulation factor Xa.

包装

1 piece contains 10 μmol Pefachrome® FXA

法律信息

Pefachrome is a registered trademark of Pentapharm AG, Basel

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

预防措施声明

P261 - P305 + P351 + P338

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCBH9022V

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Marjory B Brooks
Veterinary clinical pathology, 33(4), 208-214 (2004-12-01)
Unfractionated heparin (UFH) has a complex pharmacologic profile that necessitates patient monitoring to prevent inadequate anticoagulation or overdosage and hemorrhage. Factor Xa inhibitory assays (to measure anti-Xa activity) are used to adjust UFH dosage and define safe and effective regimens
An optimised, rapid chromogenic assay, specific for measuring direct factor Xa inhibitors (rivaroxaban) in plasma.
Meyer Michel Samama et al.
Thrombosis and haemostasis, 104(5), 1078-1079 (2010-09-02)
Job Harenberg et al.
Journal of thrombosis and thrombolysis, 32(3), 267-271 (2011-08-04)
Rivaroxaban and other oral direct factor Xa inhibitors (ODiXa) are currently developed for prophylaxis and treatment of thromboembolic diseases using fixed doses. Although routine monitoring is not required, assessing the intensity of anticoagulation may be useful under certain clinical conditions.

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