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Merck
CN

86305

Sigma-Aldrich

互变霉素 来源于螺旋轮丝链霉菌

≥90% (HPLC)

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关于此项目

经验公式（希尔记法）:
C41H66O13
化学文摘社编号:
109946-35-2
分子量:
766.95
Beilstein:
3583132
UNSPSC代码:
12352200
PubChem化学物质编号:
329769454
NACRES:
NA.25

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生物来源

Streptomyces spiroverticillatus

方案

≥90% (HPLC)

表单

powder

储存温度

−20°C

SMILES字符串

CO[C@@H]([C@H](O)CC(=O)[C@@H](C)[C@@H](O)CC[C@@H](C)C1O[C@]2(CC[C@@H](C)[C@H](CC[C@H](C)C(C)=O)O2)CC[C@@H]1C)[C@H](OC(=O)C[C@@H](O)C3=C(C)C(=O)OC3=O)C(C)C

InChI

1S/C41H66O13/c1-21(2)36(51-34(47)20-31(45)35-27(8)39(48)52-40(35)49)38(50-10)32(46)19-30(44)26(7)29(43)13-11-24(5)37-25(6)16-18-41(54-37)17-15-23(4)33(53-41)14-12-22(3)28(9)42/h21-26,29,31-33,36-38,43,45-46H,11-20H2,1-10H3/t22-,23+,24+,25-,26-,29-,31+,32+,33-,36+,37-,38-,41+/m0/s1

InChI key

RFCWHQNNCOJYTR-QKIDKDKQSA-N

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应用

Tautomycin from Streptomyces spiroverticillatus may be used to study its potential as an anti-fungal and anticancer agent. Tautomycin may be used as a potent and specific protein phosphatase inhibitor.

其他说明

Potent and specific inhibitor of protein phosphatases 1 and 2A

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300

预防措施声明

P264 - P301 + P310

危险分类

Acute Tox. 2 Oral

储存分类代码

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCBR9881V
BCBM1547V
BCBG8049V
BCBD6614V
BCBD1437

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Magne O Sydnes et al.
Bioorganic & medicinal chemistry, 16(4), 1747-1755 (2007-12-07)
Herein we describe the further improvement of our in-house developed firefly bioluminescence assay system for the determination of inhibition of protein phosphatase (PP). The advantage with the new system is higher sensitivity as well as being time and sample efficient.
Magne O Sydnes et al.
Chemistry, an Asian journal, 5(3), 410-420 (2009-12-17)
It has been a long journey since tautomycin (TTM) was isolated in 1987 and the discovery that it inhibited protein phosphatase 1 (PP1) more strongly than PP2A until finally the cocrystal structure of TTM and PP1 was presented early in
Jianhua Ju et al.
Organic letters, 11(7), 1639-1642 (2009-03-14)
The biosynthetic gene cluster for tautomycin (TTM), a potent protein phosphatase (PP) inhibitor has recently been characterized. Inactivation of ttmM, which encodes a putative C3' hydroxylase, afforded mutant SB6005 which accumulated three new 3'-deshydroxy TTM analogs, supporting the function of
Xiaolong Chen et al.
The Journal of antibiotics, 64(8), 563-569 (2011-07-21)
The potential of tautomycin to control oilseed rape stem rot was investigated in this paper. Tautomycin produced by Streptomyces spiroverticillatus strongly inhibited Sclerotinia sclerotiorum, which causes oilseed rape stem rot. Tautomycin showed great inhibition of the mycelial growth of S.
Scott N Pinchot et al.
American journal of surgery, 197(3), 313-319 (2009-02-28)
Carcinoids are neuroendocrine (NE) tumors with limited treatment options. Raf-1 pathway activation has been shown to suppress hormone production in carcinoid cells. We investigated a novel treatment for carcinoid cell growth based on pharmacologic Raf-1 activation using the compound tautomycin
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