89282
胸苷5 ′-二磷酸 钠盐
≥90% (HPLC)
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关于此项目
经验公式（希尔记法）:
C10H16N2O11P2 · xNa+
化学文摘社编号:
分子量:
402.19 (free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
EC Number:
306-019-3
MDL number:
产品名称
胸苷5 ′-二磷酸 钠盐, ≥90% (HPLC)
InChI key
HBYPEEZBYHQLDM-SPSULGLQSA-K
InChI
1S/C10H16N2O11P2.3Na/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18;;;/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18);;;/q;3*+1/p-3/t6-,7+,8+;;;/m0.../s1
SMILES string
[Na+].[Na+].[Na+].CC1=CN([C@H]2C[C@H](O)[C@@H](COP([O-])(=O)OP([O-])([O-])=O)O2)C(=O)NC1=O
biological source
animal
plant
assay
≥90% (HPLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless
shipped in
wet ice
storage temp.
−20°C
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Application
Thymidine ′-diphosphate (dTDP) may be used to study the distribution and kinetics of various nucleoside diphosphate kinases and dTDP specific nucleoside diphosphate kinases.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
S Schaertl et al.
The Journal of biological chemistry, 274(29), 20159-20164 (1999-07-10)
The Ser122 --> Pro mutation in human nucleoside diphosphate kinase (NDK)-B/Nm23-H2 was recently found in melanoma cells. In comparison to the wild-type enzyme, steady state activity of NDKS122P with ATP and TDP as substrates was slowed down 5-fold. We have
Chia-Yi Chien et al.
FEBS letters, 583(13), 2281-2286 (2009-06-23)
The existence of multifunctional enzymes in the nucleotide biosynthesis pathways is believed to be one of the important mechanisms to facilitate the synthesis and the efficient supply of deoxyribonucleotides for DNA replication. Here, we used the bacterially expressed yeast thymidylate
A Yano et al.
Plant molecular biology, 27(5), 1053-1058 (1995-03-01)
The GST (glutathione S-transferase)-NDK (nucleoside diphosphate kinase) fusion protein was expressed in Escherichia coli. The GST-NDK protein was capable of transferring gamma-phosphate from ATP to nucleoside diphosphates such as GDP, CDP, TDP and UDP. Western blot analysis using anti-NDK antibody
P Gonin et al.
Biochemistry, 38(22), 7265-7272 (1999-06-03)
Nucleoside diphosphate (NDP) kinases display low specificity with respect to the base moiety of the nucleotides and to the 2'-position of the ribose, but the 3'-hydroxyl is found to be important for catalysis. We report in this paper the enzymatic
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