A0637
DL-2-氨基己二酸
≥99% (TLC), powder, gliotoxic
别名:
DL-α氨基己二酸
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关于此项目
线性分子式:
HO2C(CH2)3CH(NH2)CO2H
化学文摘社编号:
分子量:
161.16
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
208-809-2
MDL number:
产品名称
DL-2-氨基己二酸, ≥99%
Quality Level
assay
≥99%
form
powder
mp
196-198 °C (lit.)
storage temp.
2-8°C
SMILES string
NC(CCCC(O)=O)C(O)=O
InChI
1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)
InChI key
OYIFNHCXNCRBQI-UHFFFAOYSA-N
Gene Information
rat ... Grin2b(24410)
Application
DL-2-氨基己二酸（AAA）已被用作一种astrotoxin 毒素，用于杀死可阻止移植的细胞有效整合到视网膜中的星形胶质细胞。它还被用作胶质毒素来研究星形胶质细胞膨胀对弯曲度的影响。
Biochem/physiol Actions
DL-2-氨基己二酸（AAA）是谷氨酸盐的六碳同系物和胶质毒性化合物。它通常用于显著减少小脑培养物中的星形胶质细胞数目，该培养物可用作研究a-氨基己二酸诱导的神经胶质毒性机制的模型。
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signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
相关内容
Product Information Sheet
H Q Wu et al.
European journal of pharmacology, 281(1), 55-61 (1995-07-25)
L-alpha-Aminoadipic acid is a lysine metabolite with neuroexcitatory properties, and has previously been shown to inhibit the production of the broad spectrum excitatory amino acid receptor antagonist kynurenic acid in brain tissue slices. The effects of L-alpha-aminoadipic acid on the
Huadong Ni et al.
Journal of neuroinflammation, 16(1), 1-1 (2019-01-05)
Despite accumulating evidence on the role of glial cells and their associated chemicals in mechanisms of pain, few studies have addressed the potential role of chemokines in the descending facilitation of chronic pain. We aimed to study the hypothesis that
Gliotoxic effects of $\alpha$-aminoadipic acid on monolayer cultures of dissociated postnatal mouse cerebellum
Huck S, et al.
Neuroscience, 12(3), 783-791 (1984)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A0637-1G | 04061826687666 |
| A0637-10G | 04061833626931 |
| A0637-5G | 04061833626948 |