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Merck
CN

A1755

Aminophylline dihydrochloride hyderate

≥98%, powder

别名:

(Theophylline)2 · Ethylenediamine, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, cmpd. with 1,2-ethanediamine (2:1), Theophylline hemiethylenediamine complex

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关于此项目

经验公式（希尔记法）:
C7H8N4O2 · 0.5C2H8N2
化学文摘社编号:
317-34-0
分子量:
210.21
NACRES:
NA.77
PubChem Substance ID:
24277691
UNSPSC Code:
41106305
EC Number:
206-264-5
MDL number:
MFCD00013221
Assay:
≥98%
Form:
powder
Quality level:
100

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Quality Level

100

assay

≥98%

form

powder

color

white to off-white

solubility

H2O: 50 mg/mL (solutions should be freshly prepared.), alcohol: insoluble

storage temp.

−20°C

SMILES string

NCCN.CN1C(=O)N(C)c2nc[nH]c2C1=O.CN3C(=O)N(C)c4nc[nH]c4C3=O

InChI

1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2

InChI key

FQPFAHBPWDRTLU-UHFFFAOYSA-N

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)

相关类别

Application

Aminophylline has been used:
  • as a positive control in the selective inhibitor of nuclear export, KPT-350 zebrafish dosing experiments
  • as a positive control for the determination of the spasmolytic activity of C. aeruginosa extracts
  • as a phosphodiesterase (PDE) inhibitor in inhibitor studies to quantify its potency to inhibit PDE4A1A and PDE3A enzyme in an assay

Biochem/physiol Actions

Aminophylline is a methylxanthine compound containing theophylline andethylenediamine in a ratio of 2:1. It acts as a bronchodilator and is used to treat chronic lung diseases like asthma, bronchitis, or emphysema.
Non-selective phosphodiesterase (PDE) inhibitor. Antiepileptic drug

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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分析证书(COA)

Lot/Batch Number
MKCT6059
MKCS2794
MKCS7148
MKCL4313
MKCJ3828

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全球贸易项目编号

货号GTIN
A1755-500G04061832281360
A1755-25G04061833342961
A1755-100G04061832895635

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