A1895
金精三羧酸
≥85% purity (titration), practical grade, powder
别名:
ATA
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关于此项目
经验公式（希尔记法）:
C22H14O9
化学文摘社编号:
分子量:
422.34
NACRES:
NA.47
PubChem Substance ID:
UNSPSC Code:
12171500
EC Number:
224-628-1
MDL number:
产品名称
金精三羧酸, practical grade, ≥85% (titration), powder
grade
practical grade
Quality Level
assay
≥85% (titration)
form
powder
technique(s)
titration: suitable
color
red to very dark red, and Red-Brown andBrown-Red
mp
300 °C (lit.)
solubility
1 M NH4OH: 10 mg/mL
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
SMILES string
OC(=O)c1cc(ccc1O)C(\c2ccc(O)c(c2)C(O)=O)=C3\C=CC(=O)C(=C3)C(O)=O
InChI
1S/C22H14O9/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31)
InChI key
GIXWDMTZECRIJT-UHFFFAOYSA-N
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Application
- 金合欢酸已用于显示出对微小隐孢子虫的抗隐孢子虫活性。
- 已用作供测试品鉴别抗冠状病毒 N7-MTase（鸟嘌呤-N7-甲基转移酶）的抑制剂。
- 曾被用作核糖核酸酶抑制剂。
Biochem/physiol Actions
易于在水溶液中聚合，形成可抑制蛋白质-核酸相互作用的稳定自由基。它是核糖核酸酶和拓扑异构酶 II 的强效抑制剂，作用机理是阻止核酸与酶的结合。其可促进酪氨酸磷酸化过程，包括 NB2 淋巴瘤细胞中的 Jak2/STAT5 通路，神经母细胞瘤细胞中的 ErbB4，以及 PC12 细胞中的 MAP 激酶、Shc 蛋白、磷脂酰肌醇 3-激酶和磷脂酶 Cγ。抑制细胞凋亡。它可阻止对 Ca2+ 不通透的 GluR2 受体的下调并抑制钙蛋白酶，这是一种在细胞凋亡过程中被活化的 Ca2+ -激活蛋白酶。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Red Light-Independent Instability of Oat Phytochrome mRNA in Vivo.
Seeley KA, et al.
Plant Cell, 4, 29-38 (1992)
Yeast-based assays for the high-throughput screening of inhibitors of coronavirus RNA cap guanine-N7-methyltransferase.
Sun Y, et al.
Antiviral Research, 104, 156-164 (2014)
In vitro and in vivo activity of aurintricarboxylic acid preparations against Cryptosporidium parvum.
Klein P, et al.
The Journal of Antimicrobial Chemotherapy, 62, 1101-1104 (2008)
Hui-Chen Hung et al.
The Journal of antimicrobial chemotherapy, 65(4), 676-683 (2010-01-22)
Enterovirus 71 (EV71) causes serious diseases in humans. The aim of this study was to examine the effects of aurintricarboxylic acid (ATA) on EV71 replication and to explore the underlying mechanism. To measure the activity of ATA in inhibiting the
Hui-Chen Hung et al.
Antiviral research, 81(2), 123-131 (2008-11-19)
There is a continuing threat that the highly pathogenic avian influenza virus will cause future influenza pandemics. In this study, we screened a library of compounds that are biologically active and structurally diverse for inhibitory activity against influenza neuraminidase (NA).
相关内容
Product Information Sheet
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A1895-5G | 04061833343159 |
| A1895-25G | 04061833343142 |
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