跳转至内容
Merck
CN

主要文件

查看所有文档

A5930

N-Acetyl-Asp-Glu

≥97% (TLC), mGluR3 agonist, powder or crystals

别名:

N-乙酰天冬氨酰谷氨酸, NAAG, 异冬谷酸

登录 查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:
C11H16N2O8
化学文摘社编号:
3106-85-2
分子量:
304.25
UNSPSC Code:
12352209
PubChem Substance ID:
24891036
NACRES:
NA.32
MDL number:
MFCD00076652
Assay:
≥97% (TLC)
Form:
powder or crystals
Quality level:
200
Storage condition:
(Tightly closed. Dry)
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

N-Acetyl-Asp-Glu, ≥97% (TLC)

Quality Level

200

assay

≥97% (TLC)

form

powder or crystals

optical activity

[α]22/D −34.5°, c = 1.1 in H2O(lit.)

storage condition

(Tightly closed. Dry)

color

white to off-white

solubility

H2O: 50 mg/mL

storage temp.

−20°C

SMILES string

CC(=O)NC(CC(O)=O)C(=O)NC(CCC(O)=O)C(O)=O

InChI

1S/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21)

InChI key

OPVPGKGADVGKTG-UHFFFAOYSA-N

Gene Information

human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907), GRM3(2913)
mouse ... GRIN1(14810), GRIN2A(14811), GRIN2B(14812), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168), GRM3(108069)
rat ... GRIN1(24408), GRIN2A(24409), GRIN2B(24410), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668), GRM3(24416)

相关类别

General description

研究领域：神经科学

Application

N-乙酰基-Asp-Glu已用于 N-乙酰化α-连接的酸性二肽酶（NAALADase）测定和亲和力实验。。它也被用作液相色谱-质谱(LC-MS)靶向代谢组学分析 和基于质谱分析的稳定同位素解析 代谢组学 （SIRM）与 13C515N2标记谷氨酰胺的代谢物标准。

Biochem/physiol Actions

N-乙酰-Asp-Glu（NAAG）是于哺乳动物大脑中发现的一种丰富的神经肽和神经递质。 NAAG用作代谢性谷氨酸受体mGluR3的激动剂。此外，它还作为N-甲基 -天冬氨酸（NMDA）受体的拮抗剂。它通过谷氨酸羧肽酶II（GCP II）依赖通路生成N-乙酰天门冬氨酸和谷氨酸。因此，它是癌细胞中的关键谷氨酸库。血浆NAAG水平可作为肿瘤进展的非侵入性生物标志物。
内源性神经递质定位于对代谢型谷氨酸受体 mGluR3 具有高亲和力的神经元中。它是 NMDA 受体的拮抗剂。它被星形胶质细胞膜上表达的羧肽酶 II 分解为 N-乙酰天门冬氨酸和谷氨酸。
内源性神经递质定位于对代谢型谷氨酸受体 mGluR3 具有高亲和力的神经元中；NMDA 受体拮抗剂。

Packaging

无底玻璃瓶。内含物在插入的融合锥体内。

Disclaimer

存放于干燥处。

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM0016
BCCK2749
BCCD9244
BCCC5011
BCBZ4373

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Rosane Gomez et al.
Biological psychiatry, 71(3), 239-246 (2011-08-23)
Ethanol modulates glutamate and γ-aminobutyric (GABA) function. However, little is known about the acute pharmacologic effects of ethanol on levels of GABA, glutamate, and other metabolites measurable in the human cortex in vivo with proton magnetic resonance spectroscopy ((1)H-MRS). Eleven
Preparation and affinity identification of glutamic acid-urea small molecule analogs in prostate cancer
Zhang Z, et al.
Oncology Letters, 12(2), 1001-1006 (2016)
Multi-omics approaches to disease
Yehudit H, et al.
Genome Biology (2017)
Frank Jessen et al.
Schizophrenia bulletin, 39(1), 197-205 (2011-09-15)
BACKGROUND : Imbalance of glutamatergic neurotransmission has been proposed as a key mechanism underlying symptoms of schizophrenia. The neuropetide N-acetylaspartylglutamate (NAAG) modulates glutamate release. NAAG provides a component of the proton magnetic resonance spectrum (1H-MRS) in humans. The signal of NAAG
Richard Bergeron et al.
Current medicinal chemistry, 19(9), 1360-1364 (2012-02-07)
At central synapses, glutamate is the main excitatory neurotransmitter. Once released from presynaptic terminals, glutamate activates a number of different glutamatergic receptors one of which is the ligand gated ionophore glutamatergic subtype N-methyl-D-aspartate receptors (NMDARs). NMDARs play a crucial role
查看所有相关文献

相关内容

Product Information Sheet - A5930

Product Information Sheet

全球贸易项目编号

货号GTIN
A5930-100MG04061833001950
A5930-25MG04061833001967

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持