A6433
Acetyl-Ser-Asp-Lys-Pro
≥97% (HPLC)
别名:
AcSDKP, Acetyl-SDKP
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关于此项目
经验公式（希尔记法）:
C20H33N5O9
化学文摘社编号:
分子量:
487.50
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
≥97% (HPLC)
form
powder
color
white
UniProt accession no.
storage temp.
−20°C
SMILES string
CC(=O)NC(CO)C(=O)NC(CC(O)=O)C(=O)NC(CCCCN)C(=O)N1CCCC1C(O)=O
InChI
1S/C20H33N5O9/c1-11(27)22-14(10-26)18(31)24-13(9-16(28)29)17(30)23-12(5-2-3-7-21)19(32)25-8-4-6-15(25)20(33)34/h12-15,26H,2-10,21H2,1H3,(H,22,27)(H,23,30)(H,24,31)(H,28,29)(H,33,34)
InChI key
HJDRXEQUFWLOGJ-UHFFFAOYSA-N
Gene Information
human ... GCG(2641)
Biochem/physiol Actions
Acetyl Ser-Asp-Lys-Pro is formed in bone marrow cells by enzymatic processing of thymosin β4. It inhibits the entry of pluripotent hemopoietic stem cells into S-phase of the cell cycle and protects against Ara-C lethality in mice. It is a specific substrate for the N-terminal active site of angiotensin converting enzyme, which is responsible for its degradation in vivo.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Nour-Eddine Rhaleb et al.
Journal of hypertension, 29(2), 330-338 (2010-11-06)
Hypertension-induced renal injury is characterized by inflammation, fibrosis and proteinuria. Previous studies have demonstrated that N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) inhibits renal damage following diabetes mellitus and antiglomerular basement membrane nephritis. However, its effects on low-renin hypertensive nephropathy are not known. Thus, we
Yuan-Wen Chen et al.
Journal of hepatology, 53(3), 528-536 (2010-07-22)
N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is an endogenous tetrapeptide which has antifibrogenic effects at physiological concentrations in various tissues. AcSDKP is produced locally in the liver, however, little is known about its biological effect in this organ. We hypothesize that basal levels of
Kenneth E Bernstein et al.
Current opinion in pharmacology, 11(2), 105-111 (2010-12-07)
Angiotensin-converting enzyme (ACE) can cleave angiotensin I, bradykinin, neurotensin and many other peptide substrates in vitro. In part, this is due to the structure of ACE, a protein composed of two independent catalytic domains. Until very recently, little was known
Mingao Wang et al.
International journal of molecular medicine, 26(6), 795-801 (2010-11-03)
It has been reported that N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) attenuates renal and cardiac inflammation as well as fibrosis in hypertensive rats. In this study, we investigated these effects using a unilateral ureteral obstruction (UUO) model. Eighteen male Wistar rats were randomly divided
C S Anthony et al.
Current medicinal chemistry, 19(6), 845-855 (2012-01-05)
Cardiovascular disease (CVD) is responsible for ∼27% of deaths worldwide, with 80% of these occuring in developing countries. Hypertension is one of the most important treatable factors in the prevention of CVD. Angiotensin-I converting enzyme (ACE) is a two-domain dipeptidylcarboxypeptidase
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