form
powder
solubility
alcohol: soluble
storage temp.
2-8°C
SMILES string
CC(=O)NCCc1c[nH]c2ccccc12
InChI
1S/C12H14N2O/c1-9(15)13-7-6-10-8-14-12-5-3-2-4-11(10)12/h2-5,8,14H,6-7H2,1H3,(H,13,15)
InChI key
NVUGEQAEQJTCIX-UHFFFAOYSA-N
Gene Information
human ... MTNR1A(4543), MTNR1B(4544)
General description
N-Acetyltryptamine is a melatonin analog present in mammalian blood. It is derived from tryptophan.
Application
N-Acetyltryptamine has been used as an internal standard in liquid chromatography-tandem mass spectrometry (LC/MS/MS). It has also been used as an internal standard in melatonin concentration assay and tandem mass spectrometry for the quantification of plasma melatonin levels.
Biochem/physiol Actions
Mixed agonist-antagonist at melatonin receptors; antioxidant.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
M L Dubocovich
The Journal of pharmacology and experimental therapeutics, 234(2), 395-401 (1985-08-01)
Melatonin (5-methoxy-N-acetyltryptamine) at picomolar concentrations (IC50, 40 pM) inhibited the calcium-dependent release of [3H]dopamine elicited at 3 Hz (2 min, 20 mA, 2 msec) from rabbit retina through activation of a site possessing the pharmacological and functional characteristics of a
Amanda Lochner et al.
Journal of pineal research, 40(1), 56-63 (2005-11-30)
Melatonin, the chief secretory product of the pineal gland, has been shown to protect the heart against ischemia-reperfusion injury. This was attributed to its free radical scavenging and broad-spectrum antioxidant properties. The possibility that melatonin may act via its receptor
Rashidul Haque et al.
Molecular vision, 9, 52-59 (2003-03-12)
Arylalkylamine N-acetyltransferase (AANAT) is a key regulatory enzyme in the synthesis of melatonin, which displays daily fluctuations in chicken retinal photoreceptors in vivo. The purpose of the present study was to determine if cultures of embryonic neural retina cells express