A8264
4-氨基邻苯二甲酰肼
≥98% (HPLC), powder
别名:
6-氨基-2,3-二氢-1,4-酞嗪二酮, 异鲁米诺
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关于此项目
经验公式（希尔记法）:
C8H7N3O2
化学文摘社编号:
分子量:
177.16
NACRES:
NA.83
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
Beilstein/REAXYS Number:
164804
产品名称
4-氨基邻苯二甲酰肼,
InChI
1S/C8H7N3O2/c9-4-1-2-5-6(3-4)8(13)11-10-7(5)12/h1-3H,9H2,(H,10,12)(H,11,13)
SMILES string
Nc1ccc2C(=O)NNC(=O)c2c1
InChI key
HUDPLKWXRLNSPC-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
mp
300 °C (lit.)
solubility
2 M NH4OH: 50 mg/mL, clear to slightly hazy
Quality Level
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Application
4-氨基邻苯二甲酰肼（异鲁米诺）已用于：
- 假结核耶氏菌感染后骨髓(BM)中性粒细胞的化学发光法活性氧(ROS)检测
- 克雷伯氏肺炎菌(K. pneumonia)暴露后中性粒细胞的活性氧检测
- 甲酰-蛋氨酸-亮氨酸-脯氨酸刺激后中性粒细胞的活性氧检测
Biochem/physiol Actions
4-氨基邻苯二甲酰肼或异鲁米诺是由酞嗪环构成的化学发光试剂，亲水性更高于鲁米诺。异鲁米诺在商业上广泛用于各种体外免疫分析，是可用于研究活性氧的放大性化学发光试剂。异鲁米诺也可用作电发光生物传感器(ECL)和微生物快速检测探针。
Features and Benefits
能发出化学荧光。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Caifeng Ding et al.
Chemical communications (Cambridge, England), 46(42), 7990-7992 (2010-09-25)
A new strategy of photoelectrochemical (PEC) analysis with chemiluminescence (CL) of the isoluminol-H(2)O(2)-Co(2+) system as a light source for the determination of physiological thiols in cancer cells was reported for the first time.
Viera Jancinová et al.
Redox report : communications in free radical research, 11(3), 110-116 (2006-06-30)
To address the question why isoluminol, but not luminol, failed to detect oxidants produced intracellularly, differences between these luminophores were investigated with respect to physicochemical parameters and the character of chemiluminescence signal. Our results showed the isoluminol molecule to be
Kazuhiko Tsukagoshi et al.
Journal of chromatography. A, 1143(1-2), 288-290 (2007-02-03)
In our previous study, we developed capillary electrophoresis with an ultraviolet absorption/chemiluminescence dual detection system. Here, to demonstrate one of the possible applications of the capable system as well as confirm the advantage, migration behavior of isoluminol isothiocyanate-labeled alpha-amino acids
B G Yushkov et al.
Bulletin of experimental biology and medicine, 150(3), 352-354 (2011-01-18)
The effects of 3-aminophthalhydrazide and carrageenan on reparative regeneration and expression of CD117 by liver cells after partial hepatectomy were studied in mice. 3-Aminophthalhydrazide stimulated regeneration of the liver and increased the count of CD117(+) hepatocytes. By contrast, carrageenan inhibited
Sundar Neelakantan et al.
Bioorganic & medicinal chemistry letters, 19(19), 5722-5726 (2009-08-25)
Rapid assays for bacteria have been developed utilizing novel LysLysLys-isoluminol (14) and GluGlu-isoluminol (16) probes that have been derived from peptides which potentially mimic bacteriophage attachment protein binding regions. Compared to two conventional methods that are widely used, namely nucleic
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