AV35821
抗-ZIC2 兔抗
affinity isolated antibody
别名:
抗-HPE5, 抗-Zic家族成员2(odd-paired homolog, 果蝇)
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
mol wt
55 kDa
species reactivity
human
concentration
0.5 mg - 1 mg/mL
technique(s)
immunohistochemistry: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ZIC2(7546)
Immunogen
对应人ZIC2 C末端区域的合成肽
Biochem/physiol Actions
ZIC2是一种C2H2型锌指蛋白，可作为转录抑制子，调节多巴胺受体D1的组织特异性表达。ZIC2表达对于神经系统发育和神经突起生长比较重要。ZIC2可抑制胚胎发育期间Wnt/β-连环蛋白介导的信号转导。
Physical form
本品为溶于1x PBS缓冲液的纯化抗体，含 0.09% (w/v) 叠氮化钠和2%蔗糖。
Other Notes
合成肽位于以下区域内： EPQSSSNLSPAAAAAAAAAAAAAAAVSAVHRGGGSGSGGAGGGSGGGSGS
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
常规特殊物品
此项目有
Y Zhang et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 25(6), 538-541 (2013-02-19)
From a forward genetic screen in mice we isolated a novel Zic2 allele with abnormal aggregation of meconium in the gastrointestinal tract. Zic2(m1Nisw) mutant embryos show an increase in the number of enteric neurons in vivo and disorganization of the
Zhi-Hua Liu et al.
International journal of cancer, 147(2), 505-518 (2020-02-18)
Although early detection and systemic therapies have improved the diagnosis and clinical cure rate of breast cancer, breast cancer remains the most frequently occurring malignant cancer in women due to a lack of sufficiently effective treatments. Thus, to develop potential
Rasoul Pourebrahim et al.
The Journal of biological chemistry, 286(43), 37732-37740 (2011-09-13)
The Zic transcription factors play critical roles during embryonic development. Mutations in the ZIC2 gene are associated with human holoprosencephaly, but the etiology is still unclear. Here, we report a novel function for ZIC2 as a regulator of β-catenin·TCF4-mediated transcription.
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