AV36668
Anti-MCM8 antibody produced in rabbit
affinity isolated antibody
别名:
Anti-C20orf154, Anti-MGC119522, Anti-MGC119523, Anti-MGC12866, Anti-MGC4816, Anti-Minichromosome maintenance complex component 8, Anti-REC, Anti-dJ967N21.5
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
94 kDa
species reactivity
bovine, rabbit, human, guinea pig, horse, rat, mouse
concentration
0.5 mg - 1 mg/mL
technique(s)
immunohistochemistry: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MCM8(84515)
Immunogen
Synthetic peptide directed towards the C terminal region of human MCM8
Biochem/physiol Actions
Minichromosome maintenance complex component 8 (MCM8) is one of the mini-chromosome maintenance proteins that are crucial for eukaryotic genome replication. MCM proteins are key components of the pre-replication complex, recruit replication-related proteins and form replication forks. MCM8 complexes with MCM9 to recruit RAD51 at the sites of DNA damage to facilitate homologous recombination.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: IRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQH
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
The dimeric Mcm8-9 complex of Xenopus laevis likely has a conserved function for resistance to DNA damage.
Masato T Kanemaki
Cell cycle (Georgetown, Tex.), 12(9), 1338-1339 (2013-04-17)
Jonghoon Park et al.
Molecular and cellular biology, 33(8), 1632-1644 (2013-02-13)
The minichromosome maintenance protein homologs MCM8 and MCM9 have previously been implicated in DNA replication elongation and prereplication complex (pre-RC) formation, respectively. We found that MCM8 and MCM9 physically associate with each other and that MCM8 is required for the
Matthew L Bochman et al.
Microbiology and molecular biology reviews : MMBR, 73(4), 652-683 (2009-12-01)
The Mcm2-7 complex serves as the eukaryotic replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. Consistent with its central role in this process, much prior work has illustrated that Mcm2-7 loading
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