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C1159

环丝氨酸

Name: <SC/>环丝氨酸
Brand: SIGMA

≥95% (TLC), ketosphinganine synthetase inhibitor, powder

别名:

(S)-4-Amino-3-isoxazolidone

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关于此项目

经验公式（希尔记法）:

C₃H₆N₂O₂

化学文摘社编号:

339-72-0

分子量:

102.09

NACRES:

NA.77

PubChem Substance ID:

24278296

eCl@ss:

32160406

UNSPSC Code:

12352202

EC Number:

206-427-0

MDL number:

MFCD00064324

Beilstein/REAXYS Number:

80799

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属性

产品名称

环丝氨酸,

assay

≥95% (TLC)

Quality Level

200

form

powder

mp

146 °C

solubility

H₂O: 50 mg/mg protein

storage temp.

−20°C

SMILES string

N[C@H]1CONC1=O

InChI

1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m0/s1

InChI key

DYDCUQKUCUHJBH-REOHCLBHSA-N

说明

Biochem/physiol Actions

Blocks sphingosine biosynthesis by inhibition of ketosphinganine synthetase. Cytotoxicity toward neuroblastoma and medulloblastoma cells mediated by suppression of ganglioside synthesis.

L-cycloserine is a potent inhibitor of serine palmitoyltransferase, the first step of sphingolipid synthesis.

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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Glutaminase Inhibition on NSCLC Depends on Extracellular Alanine Exploitation.

Elisa Caiola et al.

Cells, 9(8) (2020-07-29)

Non-small-cell lung cancer (NSCLC) cell lines vary in their sensitivity to glutaminase inhibitors, so it is important to identify the metabolic assets underling their efficacy in cancer cells. Even though specific genetic lesions such as in KRAS and LKB1 have

Cytotoxicity of L-cycloserine against human neuroblastoma and medulloblastoma cells is associated with the suppression of ganglioside expression.

J Cinatl et al.

Anticancer research, 19(6B), 5349-5354 (2000-03-04)

Human neuroblastoma and medulloblastoma express abnormal ganglioside patterns especially GD2 and GM2 which are important for tumour growth. We tested the effects of L-cycloserine (L-CS), a potent inhibitor of synthesis of glycosphingolipids, on the growth, viability and expression of GD2

Palmitic acid and ergosta-7,22-dien-3-ol contribute to the apoptotic effect and cell cycle arrest of an extract from Marthasterias glacialis L. in neuroblastoma cells.

David M Pereira et al.

Marine drugs, 12(1), 54-68 (2013-12-26)

We describe the effect of a chemically characterized lipophilic extract obtained from Marthasterias glacialis L. against human breast cancer (MCF-7) and human neuroblastoma (SH-SY5Y) cell lines. Evaluation of DNA synthesis revealed that both cell lines were markedly affected in a

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全球贸易项目编号

货号	GTIN
C1159-25MG	04061832940977
C1159-100MG	04061832940946
C1159-10MG	04061832940953
C1159-250MG	04061832940960