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Merck
CN

C6506

4-氯-DL-苯丙氨酸

greener alternative

5-HT synthesis inhibitor, solid

别名:

PCP, PCPA

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关于此项目

线性分子式:
ClC6H4CH2CH(NH2)CO2H
化学文摘社编号:
7424-00-2
分子量:
199.63
NACRES:
NA.32
PubChem Substance ID:
24278081
UNSPSC Code:
12352209
EC Number:
231-051-9
MDL number:
MFCD00002601

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产品名称

4-氯-DL-苯丙氨酸,

InChI

1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)

InChI key

NIGWMJHCCYYCSF-UHFFFAOYSA-N

SMILES string

NC(Cc1ccc(Cl)cc1)C(O)=O

form

solid

greener alternative product score

old score: 2
new score: 1
Find out more about DOZN™ Scoring

greener alternative product characteristics

Less Hazardous Chemical Syntheses
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

mp

>240 °C (dec.) (lit.)

greener alternative category

, Re-engineered

storage temp.

room temp

Quality Level

100

Gene Information

human ... TPH1(7166), TPH2(121278)

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相关类别

General description

我们竭诚为您带来满足绿色替代产品四大类别要求的替代产品。本品属于重新设计产品类别，在“危险性较小的化学合成”、“设计更安全的化学品和产品”和“节能设计”绿色化学原则方面取得了重大改进。 点击此处查看其 DOZN 记分卡。

Application

4-氯-DL-苯丙氨酸用于：
  • 作为色氨酸羟化酶1（TPH1）抑制剂，处理 kras+ 雄性斑马鱼
  • 在大鼠模型中诱发失眠
  • 处理胚胎，检查其对5-羟色胺的影响
  • 选择带 pESentA32质粒的粪肠球菌（ Enterococcus faecalis ）转化体
  • 饲喂苍蝇，研究5-羟色胺的作用

Biochem/physiol Actions

4-氯-DL-苯丙氨酸（PCPA）是5-羟色胺（5-HT）合成抑制剂。有助于改善肺部组织炎症和重塑肺动脉。PCPA 可减少色氨酸羟化酶1（TPH1）、基质金属蛋白酶（MMP）和促炎因子的表达。
色氨酸羟化酶抑制剂。

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H317

Hazard Classifications

Acute Tox. 3 Oral - Skin Sens. 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SHBT1902
SHBR7239
SHBQ3488
SHBM8911
SHBM3004

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Frederic D L Leusch et al.
Chemosphere, 191, 868-875 (2017-11-07)
Environmental chemicals can induce thyroid disruption through a number of mechanisms including altered thyroid hormone biosynthesis and transport, as well as activation and inhibition of the thyroid receptor. In the current study six in vitro bioassays indicative of different mechanisms of
PCPA protects against monocrotaline-induced pulmonary arterial remodeling in rats: potential roles of connective tissue growth factor
Bai Y, et al.
Testing, 8(67), 111642-111642 (2017)
Hadas Tsivion-Visbord et al.
Translational psychiatry, 10(1), 305-305 (2020-09-03)
Schizophrenia is a debilitating psychiatric disorder with a significant number of patients not adequately responding to treatment. Phencyclidine (PCP) is used as a validated model for schizophrenia, shown to reliably induce positive, negative and cognitive-like behaviors in rodents. It was
Carmine Guarino et al.
Scientific reports, 9(1), 11522-11522 (2019-08-10)
Native plant species were screened for their remediation potential for the removal of Polycyclic Aromatic Hydrocarbons (PAHs) contaminated soil of Bagnoli brownfield site (Southern Italy). Soils at this site contain all of the PAHs congeners at concentration levels well above
Mustafa Alshawaqfeh et al.
Biology direct, 12(1), 4-4 (2017-02-02)
Recent developments of high throughput sequencing technologies allow the characterization of the microbial communities inhabiting our world. Various metagenomic studies have suggested using microbial taxa as potential biomarkers for certain diseases. In practice, the number of available samples varies from
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