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C7041

McN-A-343

≥98% (TLC)

别名:

(4-羟基-2-丁炔基)-1-三甲基铵-3-氯苯基­氨基甲酸酯氯化物, 4-[N-(3-氯苯基)氨基甲酰氧]-2-丁炔基­三甲基氯化铵

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关于此项目

经验公式（希尔记法）:
C14H18Cl2N2O2
化学文摘社编号:
55-45-8
分子量:
317.21
NACRES:
NA.77
PubChem Substance ID:
24277827
UNSPSC Code:
12352106
MDL number:
MFCD00055068
Assay:
≥98% (TLC)
Form:
powder
Quality level:
200
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Quality Level

200

assay

≥98% (TLC)

form

powder

color

off-white

solubility

H2O: soluble, ethanol: soluble

SMILES string

[Cl-].C[N+](C)(C)CC#CCOC(=O)Nc1cccc(Cl)c1

InChI

1S/C14H17ClN2O2.ClH/c1-17(2,3)9-4-5-10-19-14(18)16-13-8-6-7-12(15)11-13;/h6-8,11H,9-10H2,1-3H3;1H

InChI key

CXFZFEJJLNLOTA-UHFFFAOYSA-N

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
rat ... Chrm1(25229)

Biochem/physiol Actions

M1 毒蕈碱型乙酰胆碱受体激动剂。

Preparation Note

Solutions may be stored for several days at 4 °C.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000105240
0000105241
13090705
074M4003V
107M4013V

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Lauren T May et al.
Molecular pharmacology, 72(2), 463-476 (2007-05-26)
The M2 muscarinic acetylcholine receptor (mAChR) possesses at least one binding site for allosteric modulators that is dependent on the residues (172)EDGE(175), Tyr(177), and Thr(423). However, the contribution of these residues to actions of allosteric agonists, as opposed to modulators
Hinako Suga et al.
Molecular pharmacology, 78(4), 745-755 (2010-07-21)
Investigating how a test drug alters the reaction of a site-directed electrophile with a receptor is a powerful method for determining whether the drug acts competitively or allosterically, provided that the binding site of the electrophile is known. In this
Laura Oliveira et al.
Neuro-Signals, 14(5), 262-272 (2005-11-23)
At the rat motor endplate, pre-synaptic facilitatory adenosine A2A and muscarinic M1 receptors are mutually exclusive. We investigated whether these receptors share a common intracellular signalling pathway. Suppression of McN-A-343-induced M1 facilitation of [3H]ACh release was partially recovered when CGS21680C
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全球贸易项目编号

货号GTIN
C7041-25MG04061833511862
C7041-100MG04061833511855