D033
(+)-布他拉莫 盐酸盐
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C25H31NO · HCl
化学文摘社编号:
分子量:
397.98
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
form
powder
Quality Level
optical activity
[α]27/D +222° in methanol(lit.)
storage condition
desiccated
color
white
solubility
DMSO: >10 mg/mL, clear
SMILES string
Cl[H].[H][C@@]12C[C@@](O)(CCN1C[C@@]3([H])c4ccccc4CCc5cccc2c35)C(C)(C)C
InChI
1S/C25H31NO.ClH/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25;/h4-10,21-22,27H,11-16H2,1-3H3;1H/t21-,22-,25-;/m0./s1
InChI key
QZRUMKUMFJJARD-AAJWHBHYSA-N
Gene Information
human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)
Application
(+)-布他拉莫盐酸盐已被用作多巴胺受体阻滞剂，用于：
- 大脑解剖切片
- 帕金森′病标本纹状体
- 人胚胎肾细胞(HEK293 cells)
- 小鼠纹状体组织
Biochem/physiol Actions
(+)-布他拉莫是多巴胺受体拮抗剂，同时也是一种活性对映体。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Shoma Sato et al.
The Journal of physiology, 596(12), 2447-2461 (2018-04-17)
Synaptic potentiation in Drosophila is observed at cholinergic synapses between antennal lobe (AL) and mushroom body (MB) neurons in the adult brain; however, depression at the AL-MB synapses has not yet been identified. By ex vivo Ca2+ imaging in an
Miriam E Bocarsly et al.
Cell reports, 29(5), 1147-1163 (2019-10-31)
Alcohol produces both stimulant and sedative effects in humans and rodents. In humans, alcohol abuse disorder is associated with a higher stimulant and lower sedative responses to alcohol. Here, we show that this association is conserved in mice and demonstrate
Kimberly Regna et al.
BMC developmental biology, 16(1), 15-15 (2016-05-18)
Insect metamorphosis relies on temporal and spatial cues that are precisely controlled. Previous studies in Drosophila have shown that untimely activation of genes that are essential to metamorphosis results in growth defects, developmental delay and death. Multiple factors exist that