D2667
2,5-Dihydroxycinnamic acid methyl ester
≥95%, crystalline
别名:
Erbstatin analog, Methyl 2,5-dihydroxycinnamate
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关于此项目
经验公式（希尔记法）:
C10H10O4
化学文摘社编号:
分子量:
194.18
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
≥95%
form
crystalline
color
yellow
mp
181-183 °C
solubility
0.1 M NaOH: soluble, H2O: insoluble, methanol: soluble
storage temp.
−20°C
SMILES string
COC(=O)\C=C\c1cc(O)ccc1O
InChI
1S/C10H10O4/c1-14-10(13)5-2-7-6-8(11)3-4-9(7)12/h2-6,11-12H,1H3/b5-2+
InChI key
BQCNSTFWSKOWMA-GORDUTHDSA-N
Biochem/physiol Actions
Inhibitor of EGF receptor-associated tyrosine kinase.
Other Notes
Stable analog of erbstatin.
Disclaimer
Photosensitive.
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
C Y Liu et al.
The American journal of physiology, 270(6 Pt 1), C1825-C1833 (1996-06-01)
Although tyrosine kinases play an important role in cell growth and have been implicated in regulation of smooth muscle contraction, their role in agonist-induced myoplasmic Ca2+ responses is unclear. We examined effects of the tyrosine kinase inhibitors genistein and methyl
U Kralisz et al.
Thrombosis research, 86(4), 287-299 (1997-05-15)
Herbimycin A, lavendustin A, and methyl 2,5-dihydroxycinnamate were used to study the role of protein tyrosine kinases in collagen-platelet interaction. All three compounds produced a concentration dependent inhibition of platelet aggregation induced by collagen type I, characterized by values of
B H Stewart et al.
Biochimica et biophysica acta, 1356(3), 333-342 (1997-05-27)
The signal transduction events which govern major histocompatibility complex-unrestricted tumour cell destruction by nonspecific killer T lymphocytes induced with anti-CD3 antibody have not yet been determined. In this study we used pharmacologic inhibitors to investigate the role of protein tyrosine
J Zielasek et al.
Neurochemistry international, 29(1), 83-87 (1996-07-01)
Microglial cells are resident macrophages in the central nervous system (CNS) which serve specific functions in the defence of the CNS against microorganisms, the removal of tissue debris in neurodegenerative diseases or during normal development, and in autoimmune inflammatory disorders
Z I Krutetskaia et al.
Tsitologiia, 39(2-3), 164-176 (1997-01-01)
The effect of two structurally distinct tyrosine kinase inhibitors, genistein (100 microM) and methyl-2, 5-dihydroxycinnamate (25 microM) on ATP- and thapsigargin-induced Ca2+ signals in Fura-2-loaded rat peritoneal macrophages was investigated. Both compounds were shown to inhibit ATP-evoked Ca2+ entry but
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