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D5297

Dehydroisoandrosterone 3-sulfate sodium salt dihydrate

Name: Dehydroisoandrosterone 3-sulfate sodium salt dihydrate
Brand: SIGMA

≥93% (TLC), GABAA modulator, powder

别名:

5-Androsten-3β-ol-17-one sulfate sodium salt dihydrate, Prasterone sulfate sodium salt dihydrate, Sodium dehydroepiandrosterone sulfate

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经验公式（希尔记法）:

C₁₉H₂₇NaO₅S · 2H₂O

化学文摘社编号:

78590-17-7

分子量:

426.50

NACRES:

NA.77

PubChem Substance ID:

24278373

UNSPSC Code:

12352200

EC Number:

214-152-2

MDL number:

MFCD11045975

Assay:

≥93% (TLC)

Form:

powder

Quality level:

200

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产品名称

Dehydroisoandrosterone 3-sulfate sodium salt dihydrate, ≥93% (TLC), powder

Quality Level

200

assay

≥93% (TLC)

form

powder

drug control

Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada

color

white to off-white

mp

148-149 °C (dec.) (lit.)

solubility

methanol: soluble, clear to hazy

SMILES string

O.O.[Na+].C[C@]12CC[C@H]3[C@@H](CC=C4C[C@H](CC[C@]34C)OS([O-])(=O)=O)[C@@H]1CCC2=O

InChI

1S/C19H28O5S.Na.2H2O/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18;;;/h3,13-16H,4-11H2,1-2H3,(H,21,22,23);;2*1H2/q;+1;;/p-1/t13-,14-,15-,16-,18-,19-;;;/m0.../s1

InChI key

NLNMKDUYGPNWAO-OXNWJOIVSA-M

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

Application

Dehydroisoandrosterone 3-sulfate sodium salt dihydrate has been used as a supplement to induce superoxide anion production in human neutrophil granulocytes.

Biochem/physiol Actions

Dehydroisoandrosterone 3-sulfate sodium salt dihydrate is a negative allosteric modulator of GABA_A receptors.

Features and Benefits

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Differential blockade of gamma-aminobutyric acid type A receptors by the neuroactive steroid dehydroepiandrosterone sulfate in posterior and intermediate pituitary.

S L Hansen et al.

Molecular pharmacology, 55(3), 489-496 (1999-03-03)

Dehydroepiandrosterone sulfate (DHEAS) is a neuroactive steroid with antagonist action at gamma-aminobutyric acid type A (GABAA) receptors. Patch-clamp techniques were used to investigate DHEAS actions at GABAA receptors of the rat pituitary gland at two distinct loci: posterior pituitary nerve

Plasma concentration of myeloperoxidase enzyme in pre-and post-climacterial people: related superoxide anion generation

Bekesi G, et al.

Experimental Gerontology, 37(1), 137-148 (2001)

GABAergic system's Injuries Induced by Sodium Sulfite in Caenorhabditis elegans Were Prevented by the Anti-Oxidative Properties of Dehydroepiandrosterone Sulfate.

Manuel de Jesús Gallegos-Saucedo et al.

Neurotoxicity research, 38(2), 447-460 (2020-05-16)

Several pathophysiological processes involve Hypoxia conditions, where the nervous system is affected as well. We postulate that the GABAergic system is especially sensitive. Furthermore, drugs improving the resistance to hypoxia have been investigated, such as the neurosteroid dehydroepiandrosterone sulfate (DHEAS)

Dehydroepiandrosterone sulfate is neuroprotective in a reversible spinal cord ischemia model: possible involvement of GABA(A) receptors.

P A Lapchak et al.

Stroke, 31(8), 1953-1956 (2000-08-06)

Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) may function as neurotrophic or neuroprotective factors to protect central nervous system (CNS) neurons against a variety of insults, including excitotoxicity. The present study evaluated the pharmacological effects of DHEAS in a reversible spinal

Neurosteroid analogues. 6. The synthesis and GABAA receptor pharmacology of enantiomers of dehydroepiandrosterone sulfate, pregnenolone sulfate, and (3alpha,5beta)-3-hydroxypregnan-20-one sulfate.

K R Nilsson et al.

Journal of medicinal chemistry, 41(14), 2604-2613 (1998-07-03)

The unnatural enantiomers of dehydroepiandrosterone sulfate (1), pregnenolone sulfate (2), and (3alpha,5beta)-3-hydroxypregnan-20-one sulfate (3), compounds 4-6, respectively, were prepared by total steroid synthesis. The enantioselectivity of the compounds as negative modulators of the GABAA receptors present in cultured rat hippocampal

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全球贸易项目编号

货号	GTIN
D5297-1G	04061833586143
D5297-10G	04061832090481
D5297-250MG	04061833586150

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