D6413
Diloxanide furoate
别名:
2,2-Dichloro-N-(4-hydroxyphenyl)-N-methylacetamide 2-furoic acid ester
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关于此项目
经验公式（希尔记法）:
C14H11Cl2NO4
化学文摘社编号:
分子量:
328.15
UNSPSC Code:
51101500
PubChem Substance ID:
EC Number:
223-108-1
MDL number:
antibiotic activity spectrum
parasites
SMILES string
CN(C(=O)C(Cl)Cl)c1ccc(OC(=O)c2ccco2)cc1
InChI
1S/C14H11Cl2NO4/c1-17(13(18)12(15)16)9-4-6-10(7-5-9)21-14(19)11-3-2-8-20-11/h2-8,12H,1H3
InChI key
BDYYDXJSHYEDGB-UHFFFAOYSA-N
Tsukasa Fujishima et al.
Chemotherapy, 56(4), 348-352 (2010-08-20)
A mass Entamoeba histolytica infection recurred despite repeated treatments with metronidazole at a rehabilitation institution for individuals with intellectual impairments. Diloxanide furoate was administered to improve intractable intestinal amoebiasis after a recurring amoebic infection that tends to occur via coprophagy
Treatment of asymptomatic intestinal Entamoeba histolytica infection.
Joerg Blessmann et al.
The New England journal of medicine, 347(17), 1384-1384 (2002-10-25)
Julieta B Monteiro et al.
International journal of pharmaceutics, 267(1-2), 93-100 (2003-11-07)
In this study, we investigated the susceptibility to enzymatic and alkaline hydrolysis of diloxanide furoate (DF) and its cyclodextrin inclusion complexes, in aqueous solution. The cyclodextrins (CDs) utilized were beta-cyclodextrin (beta-CD), (2,6-di-O-methyl)-beta-cyclodextrin (DM-beta-CD) and (2,3,6-tri-O-methyl)-beta-cyclodextrin (TM-beta-CD). All cyclodextrins studied provided