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Merck
CN

F107

氟桂嗪 二盐酸盐

别名:

1-[双(4-氟苯基)甲基]-4-(3-苯基-2-丙烯基)哌嗪 二盐酸盐

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关于此项目

经验公式(希尔记法):
C26H26F2N2 · 2HCl
化学文摘社编号:
分子量:
477.42
EC Number:
250-216-6
UNSPSC Code:
12352203
PubChem Substance ID:
Beilstein/REAXYS Number:
4284243
MDL number:
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technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

SMILES string

Cl[H].Cl[H].Fc1ccc(cc1)C(N2CCN(CC2)C\C=C\c3ccccc3)c4ccc(F)cc4

InChI

1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;

InChI key

RXKMOPXNWTYEHI-RDRKJGRWSA-N

Biochem/physiol Actions

阻断 T 型 Ca2+/Na+ 通道。
阻断 T 型 Ca2+/Na+ 通道;抑制嗜铬细胞中由 K+ 诱导的儿茶酚胺释放。


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pictograms

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signalword

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hcodes

Hazard Classifications

Acute Tox. 4 Oral

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Qing Ye et al.
Chinese medical journal, 124(17), 2649-2655 (2011-11-02)
Although flunarizine has been widely used for migraine prophylaxis with clear success, the mechanisms of its actions in migraine prophylaxis are not completely understood. The aim of this study was to investigate the effects of flunarizine on tetrodotoxin-resistant Na(+) channels
Pedro Enrique Jiménez-Caballero et al.
Revista de neurologia, 54(6), 332-336 (2012-03-10)
Hypnic headache is an infrequent type of primary headache characterised by appearing almost exclusively during sleep and by waking the patient up. The pain is dull (generally bilateral), is not associated to autonomic signs and usually appears from the age
Barbara Budzynska et al.
Behavioural brain research, 228(1), 144-150 (2011-12-20)
The motivational component of drug withdrawal may contribute to drug seeking and relapse through the negative reinforcement-related process; thus, it is important to understand the mechanisms that mediate affective withdrawal behaviors. The present study was undertaken to examine the calcium-dependent