G3127
Gly-Sar
≥98% (TLC)
别名:
甘氨酰肌氨酸
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关于此项目
线性分子式:
NH2CH2CON(CH3)CH2COOH
化学文摘社编号:
分子量:
146.14
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
249-875-2
MDL number:
Beilstein/REAXYS Number:
1768450
产品名称
Gly-Sar,
InChI key
VYAMLSCELQQRAE-UHFFFAOYSA-N
InChI
1S/C5H10N2O3/c1-7(3-5(9)10)4(8)2-6/h2-3,6H2,1H3,(H,9,10)
SMILES string
CN(CC(O)=O)C(=O)CN
assay
≥98% (TLC)
form
powder
color
white
mp
198 °C
storage temp.
−20°C
Quality Level
Gene Information
human ... SLC15A1(6564)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Jinling Wang et al.
International journal of nanomedicine, 13, 7997-8012 (2018-12-13)
Polymeric micelles (PMs) hold promise for improving solubility and oral absorption of poorly soluble drugs. Unfortunately, the oral absorption of PMs is also limited by intestinal epithelium. To improve the oral delivery efficiency of micelles, transporter-mediated micelles could enhance the
Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1.
Ina Hubatsch et al.
Journal of medicinal chemistry, 50(21), 5238-5242 (2007-09-25)
The hPepT1-mediated transport properties of a series of 11 synthesized beta- and gamma-peptides have been studied in Caco-2 cells. The results show that several of the compounds interact with the peptide transporter, but only two beta-dipeptides act as substrates and
Junji Miyabe et al.
Journal of pharmacological sciences, 139(3), 215-222 (2019-03-06)
Boron neutron capture therapy (BNCT) is a radiotherapy utilizing the neutron capture and nuclear fission reaction of 10B taken up into tumor cells. The most commonly used boron agent in BNCT, p-borono-l-phenylalanine (BPA), is accumulated in tumors by amino acid
Jian Cang et al.
Drug metabolism and pharmacokinetics, 25(5), 500-507 (2010-09-30)
To investigate the pharmacokinetics and mechanism of intestinal absorption of JBP485 in rats, the pharmacokinetics of JBP485 were investigated in vivo both intravenously and orally. The effects of glycylsarcosine (Gly-Sar) on the uptake and transepithelial transport of JBP485 were examined
Kanae Kawai et al.
Molecular therapy. Methods & clinical development, 17, 49-57 (2020-01-01)
Because many peptide and peptide-mimetic drugs are substrates of peptide transporter 1, it is important to evaluate the peptide transporter 1-mediated intestinal absorption of drug candidates in the early phase of drug development. Although intestinal cell lines treated with inhibitors
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