H7779
维甲酸对羟基苯胺
≥95%
别名:
4-HPR, N-(4-羟基苯基)视黄酰胺, 维甲酰酚胺
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关于此项目
经验公式（希尔记法）:
C26H33NO2
化学文摘社编号:
分子量:
391.55
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
biological source
synthetic (organic)
Quality Level
assay
≥95%
form
powder
color
yellow to yellow-orange
storage temp.
−20°C
SMILES string
CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(=O)Nc2ccc(O)cc2)C(C)(C)CCC1
InChI
1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+
InChI key
AKJHMTWEGVYYSE-FXILSDISSA-N
General description
视黄酸对羟基苯胺是视黄酸的一种合成类似物。
Application
视黄酸对羟基苯胺已被用于：
- 作为合成型视黄酸用于诱导SEB-1皮脂细胞凋亡
- 作为C2C12成肌细胞的培养基补剂以检测其对神经酰胺形成的影响
- T细胞急性淋巴细胞白血病（T-ALL）中的细胞毒性检测
Biochem/physiol Actions
视黄酸对羟基苯胺又称芬维A胺，可增加活性氧、激活半胱天冬酶并诱导细胞凋亡。它还可抑制二氢神经酰胺去饱和酶，从而引起神经酰胺生物合成的减少。芬维A胺可能对培养中的人乳腺癌细胞有抗肿瘤活性。它可作为胰岛素拮抗剂，并有助于治疗胰岛素抵抗。芬维A胺或4-HPR具有用于化疗的潜力，并对视黄酸具有耐受的癌细胞具有细胞毒性。
维生素 A 酸类似物具有抗增殖活性；诱导恶性造血细胞系凋亡。
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| H7779-5MG | 04061833804735 |
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