I7256
吲哚-3-甲醇
别名:
3-吲哚甲醇
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关于此项目
经验公式（希尔记法）:
C9H9NO
化学文摘社编号:
分子量:
147.17
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352005
EC Number:
211-836-2
MDL number:
Quality level:
Quality Level
mp
96-99 °C (lit.)
storage temp.
2-8°C
SMILES string
OCc1c[nH]c2ccccc12
InChI
1S/C9H9NO/c11-6-7-5-10-9-4-2-1-3-8(7)9/h1-5,10-11H,6H2
InChI key
IVYPNXXAYMYVSP-UHFFFAOYSA-N
General description
吲哚-3-甲醇是十字花科蔬菜中产生的一种新的次生植物代谢产物，例如卷心菜、花椰菜和抱子甘蓝等。
Application
吲哚-3-甲醇用于封装聚-乳酸-co-乙醇酸 (PLGA)，以研究其对乳腺腺癌上皮细胞(MCF7)、结肠腺癌上皮细胞(Caco2)、前列腺癌上皮细胞(PC3)的体外抗癌效果。它还被用作细胞色素P4501A (CYP1A)诱导物。
Biochem/physiol Actions
吲哚-3-甲醇(I3C)激活芳烃受体(AhR)，诱导G1细胞周期阻滞和凋亡。因此，它是一种潜在的抗癌剂。此外，它通过刺激细胞色素P450酶来诱导雌二醇代谢。因此，I3C被认为是一种有效的化疗药物，用于各种类型的癌症，包括乳腺癌、前列腺癌、结肠癌和白血病。
在起始阶段抑制致癌症发生。已经证明在几种动物中具有抑制癌症发生的作用，但如果在发病后阶段给药，它会增加肿瘤的发病率。 在十字花科蔬菜中发现。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
ppe
dust mask type N95 (US), Eyeshields, Gloves
PLGA encapsulation and radioiodination of indole-3-carbinol: investigation of anticancerogenic effects against MCF7, Caco2 and PC3 cells by in vitro assays
Yildiz G, et al.
J. Radioanal. Nucl. Chem., 311(2), 1043-1052 (2017)
Profiling the hepatic effects of flutamide in rats: a microarray comparison with classical aryl hydrocarbon receptor ligands and atypical CYP1A inducers
Coe KJ, et al.
Drug Metabolism and Disposition, 34(7), 1266-1275 (2006)
Stephen Safe et al.
Cancer letters, 269(2), 326-338 (2008-05-27)
Indole-3-carbinol (I3C) conjugates are phytochemicals expressed in brassica vegetables and have been associated with the anticancer activities of vegetable consumption. I3C and its metabolite bis(3'-indolyl)methane (DIM) induce overlapping and unique responses in multiple cancer cell lines and tumors, and these
Oliver Schanz et al.
International journal of molecular sciences, 21(9) (2020-05-06)
A diet rich in vegetables and fruit is generally considered healthy because of a high content of phytochemicals, vitamins, and fiber. The phytochemical indole-3-carbinol (I3C), a derivative of glucobrassicin, is sold as a dietary supplement promising diverse health benefits. I3C
Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice
Bradlow HL, et al.
Carcinogenesis, 12(9), 1571-1574 (1991)
商品
Chronic inflammation is an underlying factor in the development and progression of many of the chronic diseases of aging, such as arthritis, atherosclerosis, diabetes, and cancer.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| I7256-1G | 04061833858097 |
| I7256-5G | 04061833858110 |
| I7256-25G | 04061833858103 |
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