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Merck
CN

K2010

α-酮戊二酸钠 钠盐

BioUltra

别名:

2-氧代戊二酸 单钠盐, 2-氧化戊二酸 单钠盐, 2-酮戊二酸钠 一元

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关于此项目

线性分子式:
HOOCCH2CH2COCOONa
化学文摘社编号:
分子量:
168.08
UNSPSC Code:
12352204
NACRES:
NA.32
PubChem Substance ID:
EC Number:
244-836-6
Beilstein/REAXYS Number:
4597521
MDL number:
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product line

BioUltra

Quality Level

assay

≥98% (perchloric acid titration)

form

powder

impurities

≤0.0005% Phosphorus (P), ≤0.1% Insoluble matter

solubility

H2O: 0.5 M, clear, colorless

anion traces

chloride (Cl-): ≤0.05%, sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%, Ca: ≤0.001%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.005%, Mg: ≤0.0005%, NH4+: ≤0.05%, Pb: ≤0.001%, Zn: ≤0.0005%

storage temp.

2-8°C

SMILES string

[Na+].OC(=O)CCC(=O)C([O-])=O

InChI

1S/C5H6O5.Na/c6-3(5(9)10)1-2-4(7)8;/h1-2H2,(H,7,8)(H,9,10);/q;+1/p-1

InChI key

MOTOGHHLNTXPTI-UHFFFAOYSA-M

Application

α-酮戊二酸钠盐已用于人犬尿氨酸氨基转移酶II(KAT-II)的抑菌谱测定。

Biochem/physiol Actions

α-酮戊二酸是L-谷氨酸的前体。
α-酮戊二酸是TCA循环中的关键中间体。它还可与细胞内释放的氮结合,从而在防止氮超载方面发挥重要作用。


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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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实验方案

We describe here a rapid and sensitive method to separate and measure D-2-OHG and L-2-OHG enantiomers using high-resolution mass spectrometry (HRMS) detection.

商品

Sigma article discusses tumor cell metabolic pathways, focusing on aerobic glycolysis and mitochondrial activity.

Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.

本文介绍了增殖活性细胞为何需要碳源和氮源合成大分子。尽管大部分肿瘤细胞利用有氧糖酵解途径并分流线粒体氧化磷酸化代谢物,但许多肿瘤细胞表现出线粒体活性增加。


Structure-based design of irreversible human KAT II inhibitors: Discovery of new potency-enhancing interactions
Tuttle JB, et al.
ACS Medicinal Chemistry Letters, 4(1), 37-40 (2012)
Amino Acids in Therapy: A Guide to the Therapeutic Application of Protein Constituents, 34-34 (1985)
N A Smirnova et al.
Biochemistry. Biokhimiia, 77(10), 1108-1119 (2012-11-20)
This review describes the catalytic mechanism, substrate specificity, and structural peculiarities of alpha-ketoglutarate dependent nonheme iron dioxygenases catalyzing prolyl hydroxylation of hypoxia-inducible factor (HIF). Distinct localization and regulation of three isoforms of HIF prolyl hydroxylases suggest their different roles in



全球贸易项目编号

货号GTIN
K2010-25G04061833611630
K2010-5G04061833868256
K2010-100G04061833621189