M3512
（±）-咪康唑 硝酸盐
imidazole antibiotic
别名:
1-（2,4-二氯-β-[（2,4-二氯苄基）氧] 苯乙基 ] 咪唑
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关于此项目
经验公式（希尔记法）:
C18H14Cl4N2O · HNO3
化学文摘社编号:
分子量:
479.14
PubChem Substance ID:
eCl@ss:
39161001
UNSPSC Code:
51102829
NACRES:
NA.85
EC Number:
245-256-6
MDL number:
Quality Level
InChI key
MCCACAIVAXEFAL-UHFFFAOYSA-N
InChI
1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)
SMILES string
ClC1=CC(Cl)=CC=C1C(OCC2=CC=C(Cl)C=C2Cl)CN3C=CN=C3.[O-][N+](O)=O
optical activity
[α]/D ±0.10° (Specific Rotation (BP))
color
white to off-white
antibiotic activity spectrum
fungi, mycobacteria
mode of action
enzyme | inhibits
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General description
化学结构：咪唑
Application
咪康唑是咪唑类抗真菌药，可局部用药和静脉输注。它用于抑制细胞色素 P450 和研究自动发光为基础的细胞色素 P450 谱 。
Biochem/physiol Actions
咪康唑与 14-α 相互作用脱甲基酶，一种麦角固醇生物合成所必需的细胞色素 P-450 酶。麦角固醇的抑制导致细胞通透性增加引起细胞内容物渗漏。咪康唑还可能抑制内源性呼吸，与细胞膜中的磷脂相互作用，抑制酵母菌转化为菌丝形式，抑制嘌呤摄取，干扰甘油三酯和磷脂的生物合成。
抗真菌唑。操作方式：抑制细胞色素 P450 依赖性 14α-脱甲基酶，它对麦角固醇的生物合成至关重要。累积 14α-甲基化固醇更改敏感真菌的膜结构，导致细胞膜通透性改变。也抑制过氧化物酶，导致细胞内过氧化物蓄积。
Preparation Note
略溶于甲醇，微溶于乙醇。在水中极微溶解。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Michele Tonelli et al.
Bioorganic & medicinal chemistry, 16(18), 8447-8465 (2008-09-02)
Eighty-five arylazoenamines, characterized by different types of aryl and basic moieties, have been synthesized and evaluated in cell-based assays for cytotoxicity and antiviral activity against a panel of ten RNA and DNA viruses. The most commonly affected viruses were, in
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