M3512
（±）-咪康唑 硝酸盐
imidazole antibiotic
别名:
1-（2,4-二氯-β-[（2,4-二氯苄基）氧] 苯乙基 ] 咪唑
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C18H14Cl4N2O · HNO3
化学文摘社编号:
分子量:
479.14
PubChem Substance ID:
eCl@ss:
39161001
UNSPSC Code:
51102829
NACRES:
NA.85
EC Number:
245-256-6
MDL number:
Quality Level
optical activity
[α]/D ±0.10° (Specific Rotation (BP))
color
white to off-white
antibiotic activity spectrum
fungi, mycobacteria
mode of action
enzyme | inhibits
SMILES string
ClC1=CC(Cl)=CC=C1C(OCC2=CC=C(Cl)C=C2Cl)CN3C=CN=C3.[O-][N+](O)=O
InChI
1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)
InChI key
MCCACAIVAXEFAL-UHFFFAOYSA-N
General description
化学结构：咪唑
Application
咪康唑是咪唑类抗真菌药，可局部用药和静脉输注。它用于抑制细胞色素 P450 和研究自动发光为基础的细胞色素 P450 谱 。
Biochem/physiol Actions
咪康唑与 14-α 相互作用脱甲基酶，一种麦角固醇生物合成所必需的细胞色素 P-450 酶。麦角固醇的抑制导致细胞通透性增加引起细胞内容物渗漏。咪康唑还可能抑制内源性呼吸，与细胞膜中的磷脂相互作用，抑制酵母菌转化为菌丝形式，抑制嘌呤摄取，干扰甘油三酯和磷脂的生物合成。
抗真菌唑。操作方式：抑制细胞色素 P450 依赖性 14α-脱甲基酶，它对麦角固醇的生物合成至关重要。累积 14α-甲基化固醇更改敏感真菌的膜结构，导致细胞膜通透性改变。也抑制过氧化物酶，导致细胞内过氧化物蓄积。
Preparation Note
略溶于甲醇，微溶于乙醇。在水中极微溶解。
Still not finding the right product?
Explore all of our products under （±）-咪康唑 硝酸盐
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Automated Luminescence-Based Cytochrome P450 Profiling Using a Simple, Elegant Robotic Platform
Brad Larson, Peter Banks, et al.
Journal of the Association for Laboratory Automation, 16, 47-55 (2011)
Francis X Cunningham et al.
Eukaryotic cell, 6(3), 533-545 (2006-11-07)
Cyanidioschyzon merolae is considered to be one of the most primitive of eukaryotic photosynthetic organisms. To obtain insights into the origin and evolution of the pathway of carotenoid biosynthesis in eukaryotic plants, the carotenoid content of C. merolae was ascertained
Michele Tonelli et al.
Bioorganic & medicinal chemistry, 16(18), 8447-8465 (2008-09-02)
Eighty-five arylazoenamines, characterized by different types of aryl and basic moieties, have been synthesized and evaluated in cell-based assays for cytotoxicity and antiviral activity against a panel of ten RNA and DNA viruses. The most commonly affected viruses were, in
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M3512-25G | 04061834050285 |
| M3512-5G | 04061834050292 |
| M3512-1G | 04061835546756 |