M5391
美托洛尔 (+)-酒石酸盐
≥98% (titration), β1-adrenoceptor antagonist, powder
别名:
(±)1-(异丙氨基)-3-[p-(β-甲氧基乙基)苯氧基] -2-丙醇 (+)-酒石酸盐, Lopressor
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关于此项目
线性分子式:
(C15H25NO3)2 · C4H6O6
化学文摘社编号:
分子量:
684.81
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
260-148-9
MDL number:
产品名称
美托洛尔 (+)-酒石酸盐, ≥98% (titration), powder
Quality Level
assay
≥98% (titration)
form
powder
color
white to off-white
solubility
H2O: 50 mg/mL
originator
Novartis
SMILES string
O[C@H]([C@@H](O)C(O)=O)C(O)=O.COCCc1ccc(OCC(O)CNC(C)C)cc1.COCCc2ccc(OCC(O)CNC(C)C)cc2
InChI
1S/2C15H25NO3.C4H6O6/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-1(3(7)8)2(6)4(9)10/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1
InChI key
YGULWPYYGQCFMP-CEAXSRTFSA-N
Gene Information
human ... ADRB1(153)
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General description
Metoprolol has antihypertensive and anti-ischemic properties. It is used to treat arrhythmias.
Application
(±)-Metoprolol (+)-tartrate salt has been used:
- to modulate the immunological parameters in various studies
- to study its effects onCa2+-calmodulin-dependent protein kinase II (CaMKII) activity in human and experimental heart failure (HF)
- to examine the contribution of the adrenergic receptors to the production of norepinephrine (NE)-mediated O2-
Biochem/physiol Actions
β1-adrenoceptor antagonist.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Other Notes
Shelf-life of the powder is at least 4 years.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
L Brynne et al.
The Journal of pharmacology and experimental therapeutics, 286(3), 1152-1158 (1998-09-11)
The concentration-effect relationship of l-propranolol and dl-metoprolol were investigated in spontaneous hypertensive rats using reduction in exercise-induced tachycardia as a pharmacodynamic endpoint. The influence of protein binding on the effect relationship was also assessed. The rats were assigned to treatment
Metoprolol
Koch-Weser J
The New England Journal of Medicine, 301(13), 698-703 (1979)
CaMKII Activity Persists During Chronic beta-Adrenoceptor Blockade in Experimental and Human Heart Failure
Dewenter M, et al.
Circulation. Heart Failure, 10(5), e003840-e003840 (2017)
The acute modulation of norepinephrine on immune responses and genes expressions via adrenergic receptors in the giant freshwater prawn, Macrobrachium rosenbergii
Chang CC, et al.
Fish & Shellfish Immunology, 46(2), 459-467 (2015)
Tyramine's modulation of immune resistance functions in Litopenaeus vannamei and its signal pathway
Kuo HW, et al.
Developmental and Comparative Immunology (2019)
商品
DISCOVER Bioactive Small Molecules for Neuroscience
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M5391-10G | 04061834059875 |
| M5391-1G | 04061834059882 |
| M5391-5G | 04061834059899 |
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