N3510
氯硝柳胺
别名:
2′,5-二氯-4′-硝基水杨酸酰替苯胺
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关于此项目
经验公式（希尔记法）:
C13H8Cl2N2O4
化学文摘社编号:
分子量:
327.12
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
EC Number:
200-056-8
Beilstein/REAXYS Number:
2820605
MDL number:
form
powder
Quality Level
antibiotic activity spectrum
parasites
mode of action
enzyme | inhibits
SMILES string
Oc1ccc(Cl)cc1C(=O)Nc2ccc(cc2Cl)[N+]([O-])=O
InChI
1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
InChI key
RJMUSRYZPJIFPJ-UHFFFAOYSA-N
Application
氯硝柳胺是驱虫药系列中的特尼酰胺。它能帮助感染人有效对抗绦虫。氯硝柳胺用于研究Wnt / Frizzled-1信号传导途径。它用于抑制NF-κB转录和DNA结合，并提高ROS水平，诱导急性髓性白血病（AML）细胞凋亡。
Biochem/physiol Actions
氯硝柳胺解偶联绦虫氧化磷酸化，抑制寄生蠕虫线粒体氧化磷酸化。它阻断肿瘤坏死因子诱导的 IκBα 磷酸化、p65 的转位和 AML 细胞中 NF-κβ 调节基因的表达。
Other Notes
50g及250g
将容器密闭保存在干燥和通风良好的地方。在干燥处保存。
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存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
农药列管产品
此项目有
Mechanism of action of reagents that uncouple oxidative phosphorylation.
E C Weinbach et al.
Nature, 221(5185), 1016-1018 (1969-03-15)
Yanli Jin et al.
Cancer research, 70(6), 2516-2527 (2010-03-11)
NF-kappaB may be a potential therapeutic target for acute myelogenous leukemia (AML) because NF-kappaB activation is found in primitive human AML blast cells. In this report, we initially discovered that the potent antineoplastic effect of niclosamide, a Food and Drug
Wenyan Lu et al.
PloS one, 6(12), e29290-e29290 (2011-12-24)
The Wnt/β-catenin signaling pathway is important for tumor initiation and progression. The low density lipoprotein receptor-related protein-6 (LRP6) is an essential Wnt co-receptor for Wnt/β-catenin signaling and represents a promising anticancer target. Recently, the antihelminthic drug, niclosamide was found to
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| N3510-250G | 04061832991672 |
| N3510-50G | 04061834116141 |