O3011
Oxiracetam
别名:
4-Hydroxy-2-oxopyrrolidine-N-acetamide
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关于此项目
经验公式（希尔记法）:
C6H10N2O3
化学文摘社编号:
分子量:
158.16
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
storage temp.
2-8°C
SMILES string
NC(=O)CN1CC(O)CC1=O
InChI
1S/C6H10N2O3/c7-5(10)3-8-2-4(9)1-6(8)11/h4,9H,1-3H2,(H2,7,10)
InChI key
IHLAQQPQKRMGSS-UHFFFAOYSA-N
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Biochem/physiol Actions
Nootropic agent, improves learning and memory, and prevents impairment of cognitive functions. Its mechanism of action in not yet known, but it is suggested to modulate glutamatergic and cholinergic neurotransmission. Protein kinase C may be involved.
Nootropic agent, improves learning and memory.
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
A Pittaluga et al.
European journal of pharmacology, 272(2-3), 203-209 (1995-01-16)
Oxiracetam, aniracetam and D-cycloserine, three putative cognition enhancers, were examined in a functional assay for NMDA receptors. Rat hippocampal slices or synaptosomes were labeled with [3H]noradrenaline and exposed to NMDA or glutamate in superfusion. NMDA (100 microM) elicited a remarkable
Y Lu et al.
Brain research, 768(1-2), 197-207 (1997-11-22)
Previous studies demonstrated that DBA/2J (DBA) mice performed poorly while C57BL/6J (C57) mice performed normally on a number of complex learning and memory tasks. Chronic oxiracetam treatment dramatically improved the performance of DBA mice but not that of C57 mice
X L Jiao et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 29(8), 570-575 (1994-01-01)
A method was developed for the determination of oxiracetam concentration in serum and urine by HPLC. Acyclovir was used as an internal standard. The analytical column was a stainless-steel column (30 mm x 4.6 mm ID) filled with 10 microns
C Mondadori et al.
Behavioural brain research, 77(1-2), 223-225 (1996-05-01)
The memory-enhancing effects of a single treatment with the GABAB antagonist CGP 36,742 (10 mg/kg) or the nootropic agent oxiracetam (100 mg/kg) given immediately after a learning experience ('post-trial') remain detectable for at least 4 months thereafter. This indicates that
R C Simpson et al.
Journal of chromatography, 631(1-2), 227-232 (1993-02-12)
Reversed-phase HPLC methodology utilizing pre-column derivatization and post-column reaction fluorimetric detection has been developed and applied to the determination of oxiracetam in human plasma. The method involves preliminary isolation of oxiracetam and internal standard from plasma by solid-phase extraction prior
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