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Merck
CN

P4670

普罗帕酮 盐酸盐

别名:

1-[2-(2-Hydroxy-3-(propylamino)propoxy)phenyl]-3-phenyl-1-propanone hydrochloride

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关于此项目

经验公式（希尔记法）:
C21H27NO3 · HCl
化学文摘社编号:
34183-22-7
分子量:
377.90
NACRES:
NA.77
PubChem Substance ID:
24278636
UNSPSC Code:
41116107
EC Number:
251-867-9
MDL number:
MFCD00079243
Form:
powder
Quality level:
100

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form

powder

Quality Level

100

originator

Abbott

storage temp.

2-8°C

SMILES string

Cl[H].CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2

InChI

1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H

InChI key

XWIHRGFIPXWGEF-UHFFFAOYSA-N

Gene Information

human ... ABCB1(5243), ADRB1(153), ADRB2(154), ADRB3(155), CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

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General description

Propafenone hydrochloride is a calcium antagonist. It functions as a Na+ and K+ channel blocker. It might be used to treat patients with systemic hypertension. Propafenone hydrochloride is associated with bradycardia and bronchospasms. It is metabolized in the liver. Propafenone hydrochloride is used to treat ventricular arrhythmias.

Application

Propafenone hydrochloride has been used in the isolation of cardiomyocytes.

Biochem/physiol Actions

Blocks hKv1.5 and ATP-sensitive K+ channels; class 1C antiarrhythmic agent that is also an antagonist at β adrenergic receptors.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCS0910
MKCN8139
MKCJ9681
MKCD0594
MKBW3969V

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Pharmacologic management of arrhythmias
Ganjehei L, et al.
Texas Heart Institute Journal, 38(4), 344-344 (2011)
Alexander Burashnikov et al.
The Journal of pharmacology and experimental therapeutics, 340(1), 161-168 (2011-10-19)
Ranolazine has been shown to produce atrial-selective depression of sodium channel-dependent parameters and suppress atrial fibrillation (AF) in a variety of experimental models. The present study contrasts the effects of ranolazine and those of a clinically used anti-AF class IC
Lori D Bash et al.
Cardiovascular drugs and therapy, 26(2), 167-179 (2012-03-16)
Rate and rhythm control are two well established treatment objectives for atrial fibrillation (AF) patients. While symptom reduction is a primary treatment goal, therapeutic practice related to cardioversion varies by region and patient, with several precautions associated with the use
Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytes
Christe G, et al.
European Journal of Pharmacology, 373(2-3), 223-232 (1999)
The multiple modes of action of propafenone
Dukes ID and Williams EMV
European Heart Journal, 5(2), 115-125 (1984)
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全球贸易项目编号

货号GTIN
P4670-5G04061834375067

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