Rabbit anti-Sirt1 Antibody, Affinity Purified

The epitope recognized by PLA0132 maps to a region between residue 700 and the C-terminus (residue 747) of human Silent Mating Type Information Regulation 2 homolog 1 using the numbering given in entry NP_036370.2 (GeneID 23411).

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Sirt1 is one of seven members of the sirtuin family of proteins that are homologous to the yeast silent information regulator 2 (Sir2), a NAD÷-dependent protein deacetylase that plays a role in lifespan in lower eukaryotes. The sirtuins are diverse in their cellular functions, and are important to the regulation of oxidative stress, and metabolism. Sirt 1 is localized to the nucleus and possesses deacetylase activity. Sirt 1 has been shown to be able to deacetylate p53, Ku70, NF-kappaB and forkhead proteins to mediate cellular resistance to stress.

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