Q2876
喹吖因氮芥 二盐酸盐
≥85% (HPLC)
别名:
氮芥喹丫因 二盐酸盐, 氮芥喹丫因 二盐酸盐 二盐酸盐
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关于此项目
经验公式（希尔记法）:
C23H28Cl3N3O · 2HCl
化学文摘社编号:
分子量:
541.77
UNSPSC Code:
12352101
NACRES:
NA.32
PubChem Substance ID:
EC Number:
224-140-9
Beilstein/REAXYS Number:
3819822
MDL number:
Quality Level
assay
≥85% (HPLC)
storage temp.
−20°C
SMILES string
Cl[H].Cl[H].COc1ccc2nc3cc(Cl)ccc3c(NC(C)CCCN(CCCl)CCCl)c2c1
InChI
1S/C23H28Cl3N3O.2ClH/c1-16(4-3-11-29(12-9-24)13-10-25)27-23-19-7-5-17(26)14-22(19)28-21-8-6-18(30-2)15-20(21)23;;/h5-8,14-16H,3-4,9-13H2,1-2H3,(H,27,28);2*1H
InChI key
JETDZFFCRPFPDH-UHFFFAOYSA-N
General description
氮芥喹丫因（Quinacrine mustard dihydrochloride） 是一种荧光吖啶染料，简称QM。在水溶液中，氯乙基迅速失去氯离子，产生氮丙啶阳离子。这些阳离子很容易与蛋白质和核酸的羧基、硫醇和杂环氮基团或其他亲核试剂发生反应。
Application
氮芥喹丫因（Quinacrine mustard dihydrochloride）用于染色中期染色体。最新应用包括玉米的 Q 带分析和鱼类的核型分析。该染料还用作锥虫的活体染色剂。
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Ahilan Saravanamuthu et al.
The Journal of biological chemistry, 279(28), 29493-29500 (2004-04-23)
Trypanothione reductase is a key enzyme in the trypanothione-based redox metabolism of pathogenic trypanosomes. Because this system is absent in humans, being replaced with glutathione and glutathione reductase, it offers a target for selective inhibition. The rational design of potent
Monika Pietrzak et al.
Biophysical chemistry, 104(1), 305-313 (2003-07-02)
The present study was designed to estimate the ability of chlorophyllin (CHL) to interact with two acridine mutagens, quinacrine mustard (QM) and acridine orange (AO), and with the antitumor anthracycline doxorubicin (Dox). To this end, aqueous solutions of QM, AO
B Ardelt et al.
International journal of oncology, 18(4), 849-853 (2001-03-17)
Chlorophyllin (CHL), the sodium and copper salt of chlorophyll, is capable of inhibiting the mutagenic activity of many chemical compounds. Several mechanisms have been advanced to explain the antimutagenic activity of CHL, including its antioxidant properties and its ability to
Michiko Inuma et al.
Zoological science, 24(6), 588-595 (2007-09-18)
"Delayed QM-fluorescence" refers to the unusual kinetics of fluorescence from most of the C-heterochromatic regions of the chromosomes of the small Japanese field mouse Apodemus argenteus. When stained with quinacrine mustard (QM-stained), these C-heterochromatic regions emit weak fluorescence immediately after
Y Obara et al.
Zoological science, 14(1), 57-64 (1997-02-01)
The small Japanese field mouse Apodemus argenteus has the diploid chromosome number of 46, carrying rather large centromeric C-heterochromatin in most of the 44 autosomes and a large amount of C-heterochromatin in the sex chromosomes: the largest subtelocentric X was
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| Q2876-100MG | 04061832539904 |
| Q2876-25MG | 04061836687908 |
| Q2876-5MG | 04061836687915 |
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