生物来源
synthetic (organic)
质量水平
方案
≥98%
表单
powder
技术
HPLC: suitable
颜色
yellow
mp
62-64 °C
运输
dry ice
储存温度
−20°C
SMILES字符串
[H]C(=O)\C=C(C)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C
InChI
1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
InChI key
NCYCYZXNIZJOKI-OVSJKPMPSA-N
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一般描述
全反式视黄醛是维生素A族的主要衍生物之一。各种食物都是维生素A的来源。它主要存在于肝脏和颜色鲜艳的蔬菜中。
应用
全反式视黄醛已被用于：
- 光遗传学实验
- 电生理学实验
- 研究AKR1B10（醛酮还原酶（AKR）超家族成员）对气道上皮细胞的视黄醛转化为视黄醇的影响
- 人子宫内膜基质细胞的蜕膜化
生化/生理作用
全反式视黄醛在体内可通过视黄醛脱氢酶作用转化为视黄酸。视黄酸是视黄酸受体 (RAR) 和类视色素 X 受体 (RXR) 的配体，这两种受体作为转录因子调控正常和恶性细胞的生长和分化。在可视和非可视系统中，视黄醛异构体也是发色团，可与 G-蛋白偶联跨膜蛋白家族的视蛋白结合，形成光敏受体。全反式视黄醛是一种强效的光敏剂。
包装
密封安瓿瓶。
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Shiho Kawamura et al.
Structure (London, England : 1993), 21(3), 426-437 (2013-02-26)
Rhodopsin, the photoreceptor pigment of the retina, initiates vision upon photon capture by its covalently linked chromophore 11-cis-retinal. In the absence of light, the chromophore serves as an inverse agonist locking the receptor in the inactive dark state. In the
Alexandria H Jaeger et al.
eLife, 7 (2018-10-12)
Each taste modality is generally encoded by a single, molecularly defined, population of sensory cells. However, salt stimulates multiple taste pathways in mammals and insects, suggesting a more complex code for salt taste. Here, we examine salt coding in Drosophila.
Ye Zhang et al.
Nature communications, 10(1), 1560-1560 (2019-04-07)
In the Drosophila antenna, different subtypes of olfactory receptor neurons (ORNs) housed in the same sensory hair (sensillum) can inhibit each other non-synaptically. However, the mechanisms underlying this underexplored form of lateral inhibition remain unclear. Here we use recordings from
Optogenetic and pharmacologic dissection of feedforward inhibition in Drosophila motion vision
Mauss AS, et al.
The Journal of Neuroscience, 34(6), 2254-2263 (2014)
Lieuwe Biewenga et al.
ACS omega, 5(5), 2397-2405 (2020-02-18)
The efficient engineering of iminium biocatalysis has drawn considerable attention, with many applications in pharmaceutical synthesis. Here, we report a tailor-made iminium-activated colorimetric "turn-on" probe, specifically designed as a prescreening tool to facilitate engineering of iminium biocatalysis. Upon complexation of
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