产品名称
全反式视黄醛, powder, ≥98%
InChI
1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
SMILES string
[H]C(=O)\C=C(C)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C
InChI key
NCYCYZXNIZJOKI-OVSJKPMPSA-N
biological source
synthetic (organic)
assay
≥98%
form
powder
technique(s)
HPLC: suitable
color
yellow
mp
62-64 °C
shipped in
dry ice
storage temp.
−20°C
Quality Level
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Biochem/physiol Actions
全反式视黄醛在体内可通过视黄醛脱氢酶作用转化为视黄酸。视黄酸是视黄酸受体 (RAR) 和类视色素 X 受体 (RXR) 的配体，这两种受体作为转录因子调控正常和恶性细胞的生长和分化。在可视和非可视系统中，视黄醛异构体也是发色团，可与 G-蛋白偶联跨膜蛋白家族的视蛋白结合，形成光敏受体。全反式视黄醛是一种强效的光敏剂。
General description
全反式视黄醛是维生素A族的主要衍生物之一。各种食物都是维生素A的来源。它主要存在于肝脏和颜色鲜艳的蔬菜中。
Packaging
密封安瓿瓶。
Application
全反式视黄醛已被用于：
- 光遗传学实验
- 电生理学实验
- 研究AKR1B10（醛酮还原酶（AKR）超家族成员）对气道上皮细胞的视黄醛转化为视黄醇的影响
- 人子宫内膜基质细胞的蜕膜化
Hai Li et al.
The Journal of biological chemistry, 291(49), 25319-25325 (2016-10-30)
Natural anion channelrhodopsins (ACRs) recently discovered in cryptophyte algae are the most active rhodopsin channels known. They are of interest both because of their unique natural function of light-gated chloride conductance and because of their unprecedented efficiency of membrane hyperpolarization
Jihye Yeon et al.
PLoS biology, 16(6), e2004929-e2004929 (2018-06-09)
Animal locomotion is mediated by a sensory system referred to as proprioception. Defects in the proprioceptive coordination of locomotion result in uncontrolled and inefficient movements. However, the molecular mechanisms underlying proprioception are not fully understood. Here, we identify two transient
Yasushi Imamoto et al.
Biochimica et biophysica acta, 1837(5), 664-673 (2013-09-12)
Cone visual pigments are visual opsins that are present in vertebrate cone photoreceptor cells and act as photoreceptor molecules responsible for photopic vision. Like the rod visual pigment rhodopsin, which is responsible for scotopic vision, cone visual pigments contain the
Smoking-induced upregulation of AKR1B10 expression in the airway epithelium of healthy individuals
Wang R, et al.
Chest, 138(6), 1402-1410 (2010)
Advanced Nutrition Micronutrients, 23-23 (2019)
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