R4278
Anti-phospho-Retinoblastoma (pSer811) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-phospho-Rb (pSer811)
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
rat, mouse, human
技术
western blot: 0.5-1.5 μg/mL using Jurkat cells in high growth phase.
UniProt登记号
运输
dry ice
储存温度
−70°C
靶向翻译后修饰
phosphorylation (pSer811)
基因信息
human ... RB1(5925)
mouse ... Rb1(19645)
rat ... Rb1(24708)
一般描述
Retinoblastoma (Rb) is a pediatric intraocular neoplasm caused due to the biallelic inactivation of the RB1 gene. Retinoblastoma is also known as RB1 (RB transcriptional corepressor 1). It is located on human chromosome 13q14. It is a tumor suppressor gene.
免疫原
synthetic phosphopeptide derived from the region of human Rb that contains Ser811.
生化/生理作用
Retinoblastoma (RB) interacts with several protein factors to control the expression of target genes which promote cell cycle arrest, apoptosis, and differentiation. It helps to modulate nucleosome and chromatin structures. Absence of RB induces prostate cancer metastasis.
外形
Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide.
未找到合适的产品？
试试我们的产品选型工具.
储存分类代码
10 - Combustible liquids
法规信息
新产品
此项目有
Roles of pRB in the Regulation of Nucleosome and Chromatin Structures
Uchida C, et al.
BioMed Research International (2016)
A Parent-of-Origin Effect Impacts the Phenotype in Low Penetrance Retinoblastoma Families Segregating the c.1981C>T/p.Arg661Trp Mutation of RB1
Eloy P, et al.
PLoS Genetics, 12(2) (2016)
RB Loss Promotes Prostate Cancer Metastasis
Thangavel C, et al.
Cancer Research, 77(4), 982-995 (2017)
Patrick J Cimino et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 27(8), 1073-1087 (2014-01-11)
Merkel cell carcinoma is a highly aggressive cutaneous neuroendocrine tumor that has been associated with Merkel cell polyomavirus in up to 80% of cases. Merkel cell polyomavirus is believed to influence pathogenesis, at least in part, through expression of the
相关内容
Datasheet
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持