R8656
Anti-Peroxiredoxin 2 (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-NKEFB, Anti-Natural killer-enhancing factor B, Anti-PRDX2, Anti-TDPX1, Anti-Thiol-specific antioxidant 1, Anti-Thioredon peroxidase 1, Anti-Torin
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IP, WB
Citations:
19
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~22 kDa
species reactivity
rat, human, mouse
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 2.0-5.0 μg using lysate of mouse 3T3 cells, western blot: 0.5-1.0 using whole extract of human HeLa cells, western blot: 1-2 μg/mL using whole extract of rat NRK cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PRDX2(7001)
mouse ... Prdx2(21672)
rat ... PRDX2(29338)
General description
Peroxiredoxin 2 is a cytosolic member of the peroxiredoxin family of antioxidant enzymes. All peroxiredoxin enzymes exist as homodimers, they contain a conserved Cys residue corresponding to Cys51 in mammalian peroxiredoxin 1 and 2 and are distributed differentially within cells.
Immunogen
synthetic peptide corresponding to amino acid residues 184-198 of human peroxiredoxin 2 conjugated to KLH. The corresponding sequence is identical in rat and mouse peroxiredoxin 2.
Application
Anti-Peroxiredoxin 2 (C-terminal) antibody produced in rabbit has been used in immunoblottingand immunoprecipitation.
Biochem/physiol Actions
Peroxiredoxin 2 has dual roles as a peroxireductase in moderately oxidative conditions and as a molecular chaperone that binds and protects denatured proteins in hyper-oxidative conditions. Peroxiredoxin 2 is involved in platelet-derived growth factor (PDGF) and tumor necrosis factor (TNF) signaling regulation and is elevated in several human cancers and neurodegenerative disorders.
Physical form
Solution in 0.01 M phophate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
低风险生物材料
此项目有
Oxidative Stress-dependent Structural and Functional Switching of a Human 2-Cys Peroxiredoxin Isotype II That Enhances HeLa Cell Resistance to H2O2-induced Cell Death
Moon JC, et al.
Test, 280(31), 28775-28784 (2005)
Andree G Pearson et al.
Redox biology, 43, 101980-101980 (2021-04-28)
Intravenous infusion of high dose (>10 g) vitamin C (IVC) is a common alternative cancer therapy. IVC results in millimolar levels of circulating ascorbate, which is proposed to generate cytotoxic quantities of H2O2 in the presence of transition metal ions. In
2-cys peroxiredoxins: emerging hubs determining redox dependency of Mammalian signaling networks
Park J, et al.
International Journal of Cell Biology (2014)
Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II
Choi MH, et al.
Nature, 435(7040), 347-353 (2005)
Markus Dagnell et al.
The Journal of biological chemistry, 292(35), 14371-14380 (2017-07-08)
Regulation of growth factor signaling involves reversible inactivation of protein tyrosine phosphatases (PTPs) through the oxidation and reduction of their active site cysteine. However, there is limited mechanistic understanding of these redox events and their co-ordination in the presence of
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