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Merck
CN

R8656

Anti-Peroxiredoxin 2 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

别名:

Anti-NKEFB, Anti-Natural killer-enhancing factor B, Anti-PRDX2, Anti-TDPX1, Anti-Thiol-specific antioxidant 1, Anti-Thioredon peroxidase 1, Anti-Torin

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203

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产品名称

Anti-Peroxiredoxin 2 (C-terminal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~22 kDa

species reactivity

rat, human, mouse

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): 2.0-5.0 μg using lysate of mouse 3T3 cells
western blot: 0.5-1.0 using whole extract of human HeLa cells
western blot: 1-2 μg/mL using whole extract of rat NRK cells

UniProt accession no.

P32119

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... PRDX2(7001)
mouse ... Prdx2(21672)
rat ... PRDX2(29338)

Application

Anti-Peroxiredoxin 2 (C-terminal) antibody produced in rabbit has been used in immunoblottingand immunoprecipitation.

Biochem/physiol Actions

Peroxiredoxin 2 has dual roles as a peroxireductase in moderately oxidative conditions and as a molecular chaperone that binds and protects denatured proteins in hyper-oxidative conditions. Peroxiredoxin 2 is involved in platelet-derived growth factor (PDGF) and tumor necrosis factor (TNF) signaling regulation and is elevated in several human cancers and neurodegenerative disorders.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Peroxiredoxin 2 is a cytosolic member of the peroxiredoxin family of antioxidant enzymes. All peroxiredoxin enzymes exist as homodimers, they contain a conserved Cys residue corresponding to Cys51 in mammalian peroxiredoxin 1 and 2 and are distributed differentially within cells.

Immunogen

synthetic peptide corresponding to amino acid residues 184-198 of human peroxiredoxin 2 conjugated to KLH. The corresponding sequence is identical in rat and mouse peroxiredoxin 2.

Physical form

Solution in 0.01 M phophate buffered saline, pH 7.4, containing 15 mM sodium azide.

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存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

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分析证书(COA)

Lot/Batch Number
0000140240
0000133455
029M4892V
067M4854V
046M4872V

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Oxidative Stress-dependent Structural and Functional Switching of a Human 2-Cys Peroxiredoxin Isotype II That Enhances HeLa Cell Resistance to H2O2-induced Cell Death
Moon JC, et al.
Test, 280(31), 28775-28784 (2005)
Andree G Pearson et al.
Redox biology, 43, 101980-101980 (2021-04-28)
Intravenous infusion of high dose (>10 g) vitamin C (IVC) is a common alternative cancer therapy. IVC results in millimolar levels of circulating ascorbate, which is proposed to generate cytotoxic quantities of H2O2 in the presence of transition metal ions. In
2-cys peroxiredoxins: emerging hubs determining redox dependency of Mammalian signaling networks
Park J, et al.
International Journal of Cell Biology (2014)
Markus Dagnell et al.
The Journal of biological chemistry, 292(35), 14371-14380 (2017-07-08)
Regulation of growth factor signaling involves reversible inactivation of protein tyrosine phosphatases (PTPs) through the oxidation and reduction of their active site cysteine. However, there is limited mechanistic understanding of these redox events and their co-ordination in the presence of
Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II
Choi MH, et al.
Nature, 435(7040), 347-353 (2005)
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Data Sheet - R8656

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