RAB0721
人PDCD1 /程序性细胞死亡蛋白1 ELISA试剂盒
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关于此项目
NACRES:
NA.84
UNSPSC Code:
41116158
Gene information:
human ... PDCD1(5133)
Input:
sample type cell culture supernatant(s)
sample type plasma
sample type serum
sample type plasma
sample type serum
Species reactivity:
human
Storage temp.:
−20°C
Shipped in:
wet ice
species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type cell culture supernatant(s)
sample type plasma
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 20 pg/mL
standard curve range: 24.58-6000 pg/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... PDCD1(5133)
General description
The antibody pair provided in this kit recognizes human Programmed Cell Death Protein 1.
Application
请参考Protocol了解详情。
Biochem/physiol Actions
Programmed cell death protein 1 (PDCD1) plays an important role in the immune regulation by acting as a negative co-stimulatory factor. It suppresses the functions and multiplication of T cells, thereby reducing the release of IL-2 (interleukin-2), IL-10 and IFN-γ (interferon γ). In the presence of tumor microenvironment, PDCD1 along with its ligand modulates T effector functioning, thereby protecting cancer cells from immune-associated rejection. Mutation in this gene is associated with symptoms and progression of multiple sclerosis and susceptibility to systemic lupus erythematosus.
Other Notes
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
存储类别
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Shinya Hirahara et al.
Lupus, 29(7), 686-696 (2020-04-09)
Programmed cell death protein 1 (PD-1) pathway plays important roles in systemic lupus erythematosus (SLE). We aimed to elucidate the association of serum soluble PD-1 (sPD-1) and related molecules with SLE and to explore their usefulness as biomarkers. We retrospectively
A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans.
Prokunina L, et al.
Nature Genetics, 32.4, 666-666 (2002)
The expression of programmed death-1 on CD4+ and CD8+ T lymphocytes in patients with type 2 diabetes and severe sepsis.
Jia Y, et al.
PLoS ONE, 11(7), 2016-2016 null
PD-1 gene polymorphic variation is linked with first symptom of disease and severity of relapsing-remitting form of MS.
Edyta P A, et al.
Journal of Neuroimmunology, 305, 115-127 (2017)
Mee Y Bartee et al.
Cancer research, 77(11), 2952-2963 (2017-03-21)
Oncolytic virotherapy represents an attractive option for the treatment of a variety of aggressive or refractory tumors. While this therapy is effective at rapidly debulking directly injected tumor masses, achieving complete eradication of established disease has proven difficult. One method
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