主要文件

查看所有文档

S0532

番木鳖碱

Name: 番木鳖碱
Brand: SIGMA

Glycine receptor antagonist

别名:

(-)-番木鳖碱

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₂₁H₂₂N₂O₂

化学文摘社编号:

57-24-9

分子量:

334.41

NACRES:

NA.54

PubChem Substance ID:

24899441

UNSPSC Code:

12352210

EC Number:

200-319-7

MDL number:

MFCD00005941

Beilstein/REAXYS Number:

52979

Quality level:

200

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

产品名称

番木鳖碱,

Quality Level

200

mp

284-286 °C (lit.)

solubility

chloroform: soluble, clear to hazy

SMILES string

[H][C@@]12CC(=O)N3c4ccccc4[C@]56CC[N@H]7CC(=CCO1)[C@]([H])(C[C@@H]57)[C@]2([H])[C@]36[H]

InChI

1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1

InChI key

QMGVPVSNSZLJIA-FVWCLLPLSA-N

正在寻找类似产品? 访问产品对比指南

General description

Strychnine is a colorless, odourless and bitter tasting powder. It is absorbed in skin, gastrointestinaland respiratory tract. Strychnine generates oxides of nitrogen and carbon on decomposition.

Strychnine is a glycine receptor antagonist not associated with the N-methyl-D-aspartate (NMDA) receptor. It is an alkaloid extracted from Strychnos nux vomica seeds.

Application

Strychnine has been used as a glycine receptors antagonist in hippocampal CA1 pyramidal and rostral ventromedial medulla (RVM) neurons. It has also been used as type C glycine receptor antagonist in direction selective (DS) retinal cells.

Strychnine has been used in antagonist profiling to characterize a novel nicotinic receptor in Aplysia neuroendocrine cells.

Biochem/physiol Actions

At low doses, strychnine is used for circulatory problems, gastrointestinal disorders and eye diseases.

Strychnine is used as a rodenticide and a glycine receptor antagonist, which inhibits Renshaw cell-motor neuron synapse. It binds to the α subunit N-terminal region of the glycine receptor. The effect of strychnine is neutralized in the presence of glycine receptor agonist ivermectin. Strychnine also inhibits leukocyte motility.

惊厥剂；与 NMDA 受体无关的甘氨酸受体拮抗剂。

pictograms

GHS06,GHS09

signalword

Danger

hcodes

H300 + H310,H410

pcodes

P262 - P264 - P273 - P280 - P301 + P310 - P302 + P352 + P310

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Oral - Aquatic Acute 1 - Aquatic Chronic 1

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 2

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

涉药品监管产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

In vivo protection against strychnine toxicity in mice by the glycine receptor agonist ivermectin

Maher A, et al.

BioMed Research International (2014)

Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient

Woo J, et al.

Experimental Neurobiology, 28(1), 30-42 (2019)

Glycine-gated chloride channels in neutrophils attenuate calcium influx and superoxide production

WHEELER M, et al.

Faseb Journal, 14(3), 476-484 (2000)

A brainstem-spinal cord inhibitory circuit for mechanical pain modulation by GABA and enkephalins

Franccois A, et al.

Neuron, 93(4), 822-839 (2017)

Gasping is elicited by briefer hypoxia or ischemia following blockade of glycinergic transmission.

St-John WM and Leiter JC

Respiratory Physiology & Neurobiology, 133(1-2), 167-171 (2002)

查看所有相关文献

全球贸易项目编号

货号	GTIN
S0532-25G	04061836830304
S0532-5G	04061836830311
S0532-10G	04061833026694
S0532-100G	04061833026687

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持