S4026
甲基环己亚硝脲
别名:
N-（2-氯乙基）-N′-（4-甲基环己基）-N-亚硝基脲, 甲基-CCNU
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关于此项目
经验公式（希尔记法）:
C10H18ClN3O2
化学文摘社编号:
分子量:
247.72
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
InChI
1S/C10H18ClN3O2/c1-8-2-4-9(5-3-8)12-10(15)14(13-16)7-6-11/h8-9H,2-7H2,1H3,(H,12,15)
SMILES string
CC1CCC(CC1)NC(=O)N(CCCl)N=O
InChI key
FVLVBPDQNARYJU-UHFFFAOYSA-N
Application
常用于药理学研究，包括：
- 对营养敏感的筛选，用于将能量代谢从线粒体呼吸转变为糖酵解的药物
- CEOP方案结合司莫司汀，用于淋巴瘤患者的诱导化疗
- 应用于化疗的研究
signalword
Danger
Hazard Classifications
Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Carc. 1B - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
[Advances in research on capecitabine as adjuvant treatment for colon cancer after radical resection].
Su-Zhan Zhang
Zhonghua zhong liu za zhi [Chinese journal of oncology], 32(11), 801-803 (2011-01-13)
Baoqing Bai et al.
Rapid communications in mass spectrometry : RCM, 25(14), 2027-2034 (2011-06-24)
Chloroethynitrosoureas (CENUs) are important alkylating agents widely used in the treatment of cancers. Decomposition of CENUs generates active electrophilic ions that damage DNA, including the formation of dG-dC crosslinks which represents the most important cytotoxic mechanism of CENUs. In this
Eleana Ntatsaki et al.
Rheumatology (Oxford, England), 50(6), 1019-1024 (2011-02-05)
The ANCA-associated vasculitides (AAVs) are conventionally treated with a strategy of remission induction followed by maintenance therapy using glucocorticoids combined with CYC during induction and AZA for maintenance. Recently, several randomized controlled trials have been published that question whether these
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.
Report on carcinogens : carcinogen profiles, 11, III53-III53 (2004-01-01)
Xuejun Ma et al.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 93(3), 492-497 (2009-09-29)
In this randomized phase II study, we evaluated the efficacy of semustine added to CEOP regimen as induction chemotherapy in patients with stage I(E)/II(E) extranodal NK/T-cell lymphoma, nasal type in the upper aerodigestive tract. Seventy-five eligible patients were randomized to
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