S8385
[pGlu5, N-Me-Phe8, Sar9]-Substance P Fragment 5-11
≥95% (HPLC)
别名:
pGlu-Gln-Phe-N-Methyl-Phe-Sar-Leu-Met-NH2
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关于此项目
经验公式（希尔记法）:
C43H61N9O9S
化学文摘社编号:
分子量:
880.06
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
≥95% (HPLC)
UniProt accession no.
storage temp.
−20°C
SMILES string
CSCCC(NC(=O)C(CC(C)C)NC(=O)CN(C)C(=O)C(Cc1ccccc1)N(C)C(=O)C(Cc2ccccc2)NC(=O)C(CCC(N)=O)NC(=O)C3CCC(=O)N3)C(N)=O
InChI
1S/C43H61N9O9S/c1-26(2)22-32(41(59)48-29(38(45)56)20-21-62-5)47-37(55)25-51(3)43(61)34(24-28-14-10-7-11-15-28)52(4)42(60)33(23-27-12-8-6-9-13-27)50-40(58)31(16-18-35(44)53)49-39(57)30-17-19-36(54)46-30/h6-15,26,29-34H,16-25H2,1-5H3,(H2,44,53)(H2,45,56)(H,46,54)(H,47,55)(H,48,59)(H,49,57)(H,50,58)
InChI key
IEEBRBMEXFNVKU-UHFFFAOYSA-N
Gene Information
human ... TAC1(6863)
Biochem/physiol Actions
Substance P analog which is resistant to attack by a substance P degrading enzyme.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
P J Elliott et al.
Pharmacology, biochemistry, and behavior, 37(2), 329-333 (1990-10-01)
The stable substance P analog, DiMeC7, increases spontaneous locomotor activity after infusion into the lateral ventricles or median raphe nucleus (MRN). The elevated locomotion observed after intracerebroventricular (ICV) infusion of DiMeC7 was attenuated, but not blocked, by bilateral 6-hydroxydopamine (6OHDA)
R Mathison et al.
European journal of pharmacology, 240(2-3), 163-168 (1993-08-24)
The effect of inhibiting nitric oxide synthase (N omega-nitro-L-arginine) on plasma extravasation induced by intravenously administered substance P, [pGlu5,Me-Phe8,Sar9]substance P-(5-11) or prostaglandin E2 was examined. Control rats were more responsive than diabetic rats to both substance P and [pGlu5,Me-Phe8,Sar9]-substance P-(5-11).
H Yang et al.
The American journal of physiology, 272(5 Pt 1), G987-G993 (1997-05-01)
Neurons that contain substance P (SP) and thyrotropin-releasing hormone (TRH) in medullary midline raphe nuclei project to the dorsal vagal complex (DVC). The modulatory role of SP on basal gastric acid secretion (GAS) and TRH on DVC-induced stimulation of GAS
J M Barnes et al.
Pharmacology, biochemistry, and behavior, 37(4), 839-841 (1990-12-01)
The effect on forebrain catecholamine- and indoleamine-related neurochemical levels was investigated following stimulation of the rat ventral tegmental area with the substance P analogue, DiMe-C7. DiMe-C7 (6.0 micrograms) induced a marked hyperactivity in rats with maximal response between 15 and
J Mao et al.
Brain research, 574(1-2), 157-163 (1992-03-06)
The present study examined the effects of intrathecal (i.t.) injection of calcitonin gene-related peptide (CGRP) on caudally directed biting and scratching induced by i.t. substance P (SP), bombesin (BBS), strychnine (STR), and kainic acid (KA). CGRP alone (5.25, 10.5 and
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