S8385
[pGlu5, N-Me-Phe8, Sar9]-Substance P Fragment 5-11
≥95% (HPLC)
别名:
pGlu-Gln-Phe-N-Methyl-Phe-Sar-Leu-Met-NH2
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选择尺寸
关于此项目
经验公式（希尔记法）:
C43H61N9O9S
化学文摘社编号:
分子量:
880.06
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C43H61N9O9S/c1-26(2)22-32(41(59)48-29(38(45)56)20-21-62-5)47-37(55)25-51(3)43(61)34(24-28-14-10-7-11-15-28)52(4)42(60)33(23-27-12-8-6-9-13-27)50-40(58)31(16-18-35(44)53)49-39(57)30-17-19-36(54)46-30/h6-15,26,29-34H,16-25H2,1-5H3,(H2,44,53)(H2,45,56)(H,46,54)(H,47,55)(H,48,59)(H,49,57)(H,50,58)
SMILES string
CSCCC(NC(=O)C(CC(C)C)NC(=O)CN(C)C(=O)C(Cc1ccccc1)N(C)C(=O)C(Cc2ccccc2)NC(=O)C(CCC(N)=O)NC(=O)C3CCC(=O)N3)C(N)=O
InChI key
IEEBRBMEXFNVKU-UHFFFAOYSA-N
assay
≥95% (HPLC)
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... TAC1(6863)
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Biochem/physiol Actions
Substance P analog which is resistant to attack by a substance P degrading enzyme.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
R Mathison et al.
Brain research, 644(2), 251-256 (1994-05-02)
The effects of intravenous injection of prostaglandin E2 (PGE2), substance P (SP) and a metabolically stable SP analogue, [pGlu5,Me-Phe8,Sar9]-SP (5-11) on plasma extravasation of albumin in the rat after blockade of prostaglandin synthesis with indomethacin or chemical sympathectomy with guanethidine
J M Barnes et al.
Pharmacology, biochemistry, and behavior, 37(4), 839-841 (1990-12-01)
The effect on forebrain catecholamine- and indoleamine-related neurochemical levels was investigated following stimulation of the rat ventral tegmental area with the substance P analogue, DiMe-C7. DiMe-C7 (6.0 micrograms) induced a marked hyperactivity in rats with maximal response between 15 and
J Mao et al.
Brain research, 574(1-2), 157-163 (1992-03-06)
The present study examined the effects of intrathecal (i.t.) injection of calcitonin gene-related peptide (CGRP) on caudally directed biting and scratching induced by i.t. substance P (SP), bombesin (BBS), strychnine (STR), and kainic acid (KA). CGRP alone (5.25, 10.5 and
J L Cornish et al.
Neuroscience letters, 176(2), 142-146 (1994-08-01)
Central dopaminergic systems have been implicated in the regulation of blood pressure. We examined the effect on blood pressure of electrical or chemical stimulation of the rat brain ventral tegmental area (VTA) which is the region of origin of the
M van den Buuse et al.
Clinical and experimental pharmacology & physiology, 25(7-8), 624-626 (1998-07-23)
1. Stimulation of the mesolimbic dopamine system, by micro-injection of the substance P analogue [pGlu5,MePhe8,Sar9] substance P (DiMe-C7) into the ventral tegmental area induced a prolonged increase in blood pressure and circulating levels of vasopressin. 2. In the present study
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