S8751
磺胺胍
别名:
4-氨基-N-(氨基亚氨基甲基)苯磺酰胺, 4-氨基-N-胍基苯磺酰胺
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关于此项目
经验公式（希尔记法）:
C7H10N4O2S
化学文摘社编号:
分子量:
214.24
UNSPSC Code:
51283914
NACRES:
NA.85
PubChem Substance ID:
EC Number:
200-345-9
Beilstein/REAXYS Number:
2695326
MDL number:
InChI key
BRBKOPJOKNSWSG-UHFFFAOYSA-N
InChI
1S/C7H10N4O2S/c8-5-1-3-6(4-2-5)14(12,13)11-7(9)10/h1-4H,8H2,(H4,9,10,11)
SMILES string
NC(=N)NS(=O)(=O)c1ccc(N)cc1
biological source
synthetic (Organic)
form
powder
color
white to off-white
solubility
1 M HCl: soluble 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
DNA synthesis | interferes, enzyme | inhibits
Quality Level
Gene Information
human ... F2(2147), PRSS1(5644)
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General description
化学结构：磺胺
Application
磺胺胍被用来阻止叶酸的合成。可用于研究其对微孢子生长和宿主细胞活力的影响。
Biochem/physiol Actions
磺胺胍是一种磺胺类抗生素。磺酰胺可通过抑制二氢蝶呤合酶来阻止二氢叶酸的合成。磺胺类药物是细菌对氨基苯甲酸（PABA；细菌中叶酸合成所必需）的竞争性抑制剂。磺胺胍是一种二氢叶酸还原酶（DHFR）的抑制剂。磺胺类药物对革兰氏阳性细菌和革兰氏阴性细菌具有活性。抗性模式是通过二氢蝶呤合酶的改变或叶酸合成的替代途径。
Other Notes
将容器密闭保存在干燥和通风良好的地方。在干燥处保存。储存类别 (TRGS 510)：非易燃固体
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Journal of chromatography. A, 1131(1-2), 1-10 (2006-08-02)
In recent years, pharmaceutical and personal care products (PPCPs) have been detected in diverse environments (including groundwater, river water, and municipal wastewater). In order to evaluate their environmental impact, PPCPs must first be accurately determined. In this study, we focused
B Beauvais et al.
Antimicrobial agents and chemotherapy, 38(10), 2440-2448 (1994-10-01)
We have developed a new micromethod to study the effect of drugs on microsporidia, using MRC5 fibroblasts infected by 10(5) spores of Encephalitozoon cuniculi. After 3 days of incubation with various concentrations of drugs, parasitic foci were counted in stained
H Sasaki et al.
Journal of pharmacobio-dynamics, 13(3), 200-205 (1990-03-01)
The enhancing effect of pyrrolidone derivatives on the percutaneous penetration of sulfaguanidine, aminopyrine and sudan III was investigated using in vitro technique and excised rat skin. 1-Methyl (MP), 1-hexyl (HP) and 1-lauryl-2-pyrrolidone (LP) were used as penetration enhancers. Aminopyrine showed
B W Clare et al.
Journal of enzyme inhibition, 16(1), 1-13 (2001-08-11)
A series of compounds has been prepared by reaction of dicyandiamide with alkyl/arylsulfonyl halides as well as arylsulfonylisocyanates to locate a lead for obtaining weakly basic thrombin inhibitors with sulfonyldicyandiamide moieties as the S1 anchoring group. The detected lead was
Alan D Gift et al.
Journal of pharmaceutical sciences, 98(12), 4670-4683 (2009-05-21)
Active pharmaceutical ingredients (API) can undergo an anhydrate to hydrate transformation during wet granulation and this transformation may either result in mixed crystalline forms or an unwanted form in the final drug product. Previous studies have shown that it may
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