Anti-MDM4 antibody produced in mouse

Mouse double minute 4 (MDM4), also known as MDMX, is encoded by the gene mapped to human chromosome 1q32.1. The encoded protein is a structural homolog of MDM2. It belongs to the MDM family.

The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Two transcript variants, one protein-coding and the other likely not to be protein-coding, have been found for this gene. (provided by RefSeq)

MDM4 (NP_002384.2, 1 a.a. ~ 490 a.a) full-length human protein.

Sequence
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA

Mouse double minute 4 (MDM4)/ MDMX acts as an essential regulator of the tumor suppressor Tp53. Overexpression of the gene has been observed in patients with hepatocellular carcinoma (HCC). Polymorphism in the gene increases the risk of susceptibility to gastric cancer (GCa). In addition, upregulated expression of the gene is also involved in the etiology of various cancers, such as invasive breast carcinoma liver hepatocellular carcinoma, retinoblastomas and skin cutaneous melanomas.

Solution in phosphate buffered saline, pH 7.4

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