SAB4200101
Anti-AS160 antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody
别名:
Anti-Akt substrate of 160 kDa, Anti-TBC1D4 (TBC1 domain family, member 4)
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB
Citations:
6
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~160 kDa
species reactivity
human
packaging
antibody small pack of 25 μL
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1.5 mg/mL
technique(s)
indirect immunofluorescence: 8-16 μg/mL using HEK-293T cells, western blot: 0.8-1.6 μg/mL using extracts of HEK-293T cells over expressing human AS160
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TBC1D4(9882)
mouse ... Tbc1d4(210789)
General description
AS160 (Akt substrate of 160 kDa, also known as TBC1 domain family member 4 (TBC1D4)) gene is mapped to human chromosome 13q22.2 and encodes a Rab guanosine triphosphatase (GTPase)-activating proteins (RabGAP) protein. AS160 is expressed in many differentiated tissues such as adipocytes and skeletal muscles.
Application
Anti-AS160 antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
AS160 is known to play an inhibitory role in the transport of glucose transporter 4 (GLUT4) vesicles. It is associated with GLUT4 vesicles in basal states and dissociates in response to insulin. Reduced expression of AS160 in adipocytes has been shown to increase plasma membrane levels of GLUT4 in an insulin-dependent manner.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
AS160 controls eukaryotic cell cycle and proliferation by regulating the CDK inhibitor p21
Gongpan P, et al.
Cell Cycle, 15(13), 1733-1741 (2016)
Cooperative actions of Tbc1d1 and AS160/Tbc1d4 in GLUT4-trafficking activities
Hatakeyama H, et al.
The Journal of Biological Chemistry, 294(4), 1161-1172 (2019)
Identification of a novel AS160 splice variant that regulates GLUT4 translocation and glucose-uptake in rat muscle cells
Baus D, et al.
Cellular Signalling, 20(12), 2237-2246 (2008)
Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking
Larance M, et al.
Test, 280(45), 37803-37813 (2005)
A method to identify serine kinase substrates Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain
Kane S, et al.
The Journal of biological chemistry, 277(25), 22115-22118 (2002)
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