生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~160 kDa
种属反应性
human
包装
antibody small pack of 25 μL
增强验证
recombinant expression
Learn more about Antibody Enhanced Validation
浓度
~1.5 mg/mL
技术
indirect immunofluorescence: 8-16 μg/mL using HEK-293T cells
western blot: 0.8-1.6 μg/mL using extracts of HEK-293T cells over expressing human AS160
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TBC1D4(9882)
mouse ... Tbc1d4(210789)
一般描述
AS160 (Akt substrate of 160 kDa, also known as TBC1 domain family member 4 (TBC1D4)) gene is mapped to human chromosome 13q22.2 and encodes a Rab guanosine triphosphatase (GTPase)-activating proteins (RabGAP) protein. AS160 is expressed in many differentiated tissues such as adipocytes and skeletal muscles.
应用
Anti-AS160 antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
生化/生理作用
AS160 is known to play an inhibitory role in the transport of glucose transporter 4 (GLUT4) vesicles. It is associated with GLUT4 vesicles in basal states and dissociates in response to insulin. Reduced expression of AS160 in adipocytes has been shown to increase plasma membrane levels of GLUT4 in an insulin-dependent manner.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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