SAB4200424
Anti-COG1 (C-TERMINAL) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-CDG2G, Anti-COG complex subunit 1, Anti-LDLB, Anti-component of oligomeric golgi complex 1, Anti-conserved oligomeric Golgi complex subunit 1, Anti-low density lipoprotein receptor defect
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~110 kDa
species reactivity
mouse, human, rat
concentration
~1.0 mg/mL
technique(s)
indirect immunofluorescence: 1-2 μg/mL using human HeLa cells., western blot: 2.5-5.0 μg/mL using whole extracts of mouse LA-4 cells.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... COG1(9382)
mouse ... Cog1(16834)
rat ... Cog1(303652)
General description
COG1 is a member of the conserved oligomeric Golgi (COG) complex. COG complex is an evolutionarily conserved multi-subunit protein complex. COG complex consists of eight distinct subunits organized in two heterotrimeric groups, Cog2-Cog3-Cog4 and Cog5-Cog6-Cog7, which are linked by the dimeric group formed by Cog1 and Cog8.
Conserved oligomeric Golgi (COG) subunit 1 is an essential component of the conserved oligomeric Golgi complex. It is encoded by the gene mapped to human chromosome 17q25.1.
Immunogen
peptide corresponding to the C-terminal region of human COG1, conjugated to KLH. The corresponding sequence is identical in mouse, rat and monkey COG1.
Application
Anti-COG1 (C-TERMINAL) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
COG1 is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates. It plays a role in the organization of the Golgi-localized complex. Mutations in COG1 in humans cause novel types of congenital disorders of glycosylation (CDG). COG complex regulates membrane trafficking and maintenance of Golgi glycosylation machinery in eukaryotic cells.
Conserved oligomeric Golgi (COG) complex plays a vital role in retrograde vesicular trafficking and glycosylation.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Genome-wide Examination of Chromosomal Aberrations
in Neuroblastoma SH-SY5Y Cells by Array-based Comparative
Genomic Hybridization
Do JH
Molecules and Cells, 24, 105-112 (2007)
Cerebrocostomandibular-like syndrome and a mutation in the conserved oligomeric Golgi complex, subunit 1.
Zeevaert R
Human Molecular Genetics, 18, 517-524 (2009)
Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation
Smith RD and Lupashin VV
Carbohydrate Research, 343(12), 2024-2031 (2008)
Conserved oligomeric Golgi complex specifically regulates the maintenance of Golgi glycosylation machinery
Pokrovskaya ID, et al.
Glycobiology, 21(12), 1554-1569 (2011)
Comparative analyses of the Conserved Oligomeric Golgi (COG) complex in vertebrates
Quental R, et al.
BMC Evolutionary Biology, 10(1), 212-212 (2010)
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