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Merck
CN

SAB4300076

Anti-phospho-TP53 (pSer33) antibody produced in rabbit

affinity isolated antibody

别名:

Anti-FLJ92943 antibody produced in rabbit, Anti-LFS1 antibody produced in rabbit, Anti-TRP53 antibody produced in rabbit, Anti-p53 antibody produced in rabbit, Anti-tumor protein p53 antibody produced in rabbit

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00164709
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB
Citations:
-

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~53 kDa

species reactivity

human

concentration

1 mg/mL

technique(s)

indirect immunofluorescence: 1:100-1:200, western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(V-L-SP-P-L)

NCBI accession no.

NP_000537.3

UniProt accession no.

P04637

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer33)

Gene Information

human ... TP53(7157)

General description

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.

Immunogen

Peptide sequence around phosphorylation site of serine 33 (V-L-S(p)-P-L), according to the protein TP53.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
511711097

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商品

p53: DNA Damage Response and Cancer

p53 regulates gene expression, cell cycle control and functions as a tumor suppressor. Inactivation of p53 is closely tied to cancer development.

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